Anesth Pain Med.  2015 Jul;10(3):180-186. 10.17085/apm.2015.10.3.180.

The effects of ketamine-propofol (ketofol) ratio in the mixing proportions of ketofol on hemodynamic response to endotracheal intubation

• Rim JC
• Kim DY
• Kim H
• Park JH
• Park SY
• Lee SC
• Chung CJ
• Lee JH

• KMID: 2148028
• DOI: http://doi.org/10.17085/apm.2015.10.3.180

Abstract

BACKGROUND
Hemodynamic stability can be achieved using the combination of ketamine and propofol (ketofol). This study was designed to compare the hemodynamic effects of ketofol with different ketamine-propofol ratios versus propofol after induction of general anesthesia with endotracheal intubation.
METHODS
A total of 120 American Society of Anesthesiologist physical status I and II patients 20-60 years of age were randomly allocated into one of four groups. The K0 group received only 2 mg/kg propofol. The K0.15 group received 0.15 mg/kg ketamine and 1.85 mg/kg propofol. The K0.3 group received 0.3 mg/kg ketamine and 1.7 mg/kg propofol. The K0.6 group received 0.6 mg/kg ketamine and 1.4 mg/kg propofol. Endotracheal intubation was performed after muscle relaxation. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP), heart rate (HR) and the bispectral index value were recorded.
RESULTS
No significant differences were observed in SBP, DBP, MBP, or HR among the groups after endotracheal intubation. However, the number of patients with a decrease of MBP > 20% from baseline after induction was significantly lower in the K0.6 group compared to that in the K0 group (P < 0.05).
CONCLUSIONS
The results suggest that ketofol with 0.6 mg/kg ketamine and 1.4 mg/kg propofol can be used as an alternative to 2 mg/kg propofol.

Keyword

Endotracheal intubation; Ketamine; Propofol

MeSH Terms

Anesthesia, General
Blood Pressure
Heart Rate
Hemodynamics*
Humans
Intubation, Intratracheal*
Ketamine
Muscle Relaxation
Propofol
Ketamine
Propofol