Korean J Androl.  2003 Apr;21(1):38-43.

Effects of Injectable Hyaluronic Acid Gel in Augmentation of Glans Penis

Affiliations
  • 1Department of Urology, Korea University College of Medicine, Seoul, Korea. jjkim98@korea.ac.kr
  • 2Department of Pathology, Gachon Medical School Gil Medical Center, Incheon, Korea.

Abstract

PURPOSE
Soft-tissue augmentation using hyaluronic acid (HA) gels is widely used in dermatology and plastic surgery. We performed this study to determine the feasibility of using HA gel to augment the glans penis.
MATERIALS AND METHODS
In experiment I, 0.2 cc of HA gel was injected into the dermis of the glans penis of 25 New Zealand White rabbits via a 27-gauge needle. At 3, 7, 14, 30, and 90 days after injection, the histologic changes in the penis and systemic adverse effects were evaluated. In experiment II, 0.5 cc of HA gel was injected into the dermis of the glans penis of 14 Beagle dogs. Two weeks later, an additional 0.2 cc was injected in 7 of the dogs. For 6 months, the changes in the injected area were grossly evaluated using a 10-point visual scale, and at the end of the study, histologic changes were also evaluated. At autopsy, lung, liver, and spleen were studied for systemic adverse reactions.
RESULTS
In the dogs receiving double injections, 85% to 90% of the initial volume was maintained at 6 months, with HA being identified in the lamina propria of the glans penis. Encapsulated material was confirmed to be HA by alcian blue stain and hyaluronidase immunohistochemical stain. No systemic adverse reaction was noticed in any animal.
CONCLUSIONS
Hyaluronic acid gel is safe and effective for augmentation of the glans penis. Booster injection enhances the injected volume and facilitates injection of HA.

Keyword

Glans penis; Hyaluronic acid; Penile augmentation

MeSH Terms

Alcian Blue
Animals
Autopsy
Dermatology
Dermis
Dogs
Gels
Hyaluronic Acid*
Hyaluronoglucosaminidase
Liver
Lung
Male
Mucous Membrane
Needles
Penis*
Rabbits
Spleen
Surgery, Plastic
Alcian Blue
Gels
Hyaluronic Acid
Hyaluronoglucosaminidase
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