Korean J Gastrointest Motil.
1998 May;4(1):1-12.
Functional Dyspepsia and Subgroups in Korea and Short Term Outcome of Therapeutic Trial of Cisapride: Multicenter Study
- Affiliations
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- 1Department of Internal Medicine, The Catholic University of Korea. College of Medicine, Korea.
- 2Department of Internal Medicine, Sung Kyun Kwan University College of Medicine, Korea.
- 3Department of Internal Medicine, Kangnam General Hospital, Korea.
- 4Department of Internal Medicine, Kyungpook National University College of Medicine, Korea.
- 5Department of Internal Medicine, Korea University College of Medicine, Korea.
- 6Department of Internal Medicine, Eulji Medical College, Korea.
- 7Department of Internal Medicine, Dankook University College of Medicinem, Korea.
- 8Department of Internal Medicine, Taegu-Hyosung Catholic University College of Medicine, Korea.
- 9Department of Internal Medicine, Pusan Dae Dong Hospital, Korea.
- 10Department of Internal Medicine, Ulsan Dong Kang Hospital, Korea.
- 11Department of Internal Medicine, Dongguk University Colege of Medicine, Korea.
- 12Department of Internal Medicine, Masan Samsung Hospital, Korea.
- 13Department of Internal Medicine, Boramae Hospital, Seoul, Korea.
- 14Department of Internal Medicine, Inje University College of Medicine, Korea.
- 15Department of Internal Medicine, Pochon CHA University College of Medicine, Korea.
- 16Department of Internal Medicine, Ajou University School of Medicine, Korea.
- 17Department of Internal Medicine, Yeung Nam University College of Medicine, Korea.
- 18Department of Internal Medicine, Wonkwang University College of Medicine, Korea.
- 19Department of Internal Medicine, Wonjuu College of Medicine, Korea.
- 20Department of Internal Medicine, Ewha Womans University College of Medicine, Korea.
- 21Department of Internal Medicine, Inha University College of Medicine, Korea.
- 22Department of Internal Medicine, Chonnam University Medical School, Korea.
- 23Department of Internal Medicine, Chung-Ang Gil Hospital, Korea.
- 24Department of Internal Medicine, Ulsan University College of Medicine, Korea.
- 25Department of Internal Medicine, Choongnam National University College of Medicine, Korea.
- 26Department of Internal Medicine, Chungbuk National University College of Medicine, Korea.
- 27Department of Internal Medicine, Kwanguj Christian Hospital, Korea.
- 28Department of Internal Medicine, Yonsei University College of Medicine, Korea.
- 29Department of Internal Medicine, Hallym University Collegel of Medicine, Korea.
- 30Department of Internal Medicine, Soon-Chun-Hyang University College of Medicine, Korea.
- 31Department of Internal Medicine, St, Benedict Hospital, Pusan, Korea.
- 32Department of Internal Medicine, Keimyung University School of Medicine, Korea.
Abstract
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BACKGROUND/AIMS: The aims of this study were to determine subgoups of functional dyspesia and to evaluate the short-term effect of cisapride in patients with functional dyspepsia in Korea.
METHODS
1025 patients, with a mean age of 42.6 years, with symptoms of functional dyspepsia, were recruited consecutively and upper gastrointestinal symptoms were investigated by interview in 41 hospitals in Korea. In an open, multicenter trial, 1025 patients received Smg of cisapride three times a day (TID) for at least .2 weeks for the treatment of symptoms of functional dyspepsia. When necessary, the dose of cisapride was increased to 10mg TID and the duration of therapy was extended to 4 weeks.
RESULTS
The most frequently reported symptoms of functional dyspepsia were epigastric discomfort or fullness (85%), bloating (70%), belching (53%), early satiety (52%) and epigastric pain (46%) retrospectively. Subgroups of functional dyspepsia were as follows; dysmotility-like 73.5%, ulcer-like 39.7%, reflux-like 13.0%, and unspecified dyspepsia 14.0%. However, 33.2% of subjects with functional dyspepsia could be classified into more than one subgroup. Upper gastrointestinal symptoms were decreased to average 50.3% (range; 42.2 to 59.2%) after 2 weeks of cisapride treatment and to 25% (19.2 to 29.9%) after 4 weeks. cisapride therapy resulted in good or excellent improvement in 59.0% of the patients after two weeks, in 75% of patients after 4 weeks. Adverse events were occurred in 52 patients (5.8% of all patients), most commonly, loose stools or diarrhea (3.5%), abdominal pain (1.1%), and dizziness (0.3%). The majority of adverse events was mild and transient in nature and led to premature discontinuation of treatment in 4 patients.
CONCLUSIONS
Although the majorities of patients with functional dyspepsia have dysmotility like symptoms in Korea, there is such overlap among the dyspepsia subgroups. Most patients responded well to a short therapeutic trial with cisapride without significant side effects.
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