Korean J Med.  2010 Feb;78(2):191-197.

The relationship between the ApoB/ApoA-I ratio and non-alcoholic fatty liver disease in prediabetic patients

• Lee JA
• Jang SH
• Min JH
• Kim TW
• Jeong WS
• Shim CN
• Heo WJ
• Jung MY
• Lee HA
• Cho YK
• Hong HP

Abstract

BACKGROUND/AIMS: The apolipoprotein B/A-I ratio (ApoB/A-I) is a powerful clinical indicator of atherosclerosis. Although numerous reports have shown the effect of non-alcoholic fatty liver disease (NAFLD) on cardiovascular disease, few reports have examined the relationship between NAFLD and the ApoB/A-I ratio. The aim of the study was to determine the association between NAFLD and the ApoB/A-I ratio in prediabetic patients.
METHODS
This cross-sectional study was performed with data obtained from 701 patients (mean age, 47.9+/-9.6 years) diagnosed with prediabetes. Serum lipid profiles including lipoprotein, apolipoprotein, and calculated ApoB/A-I ratio as well as metabolic syndrome parameters such as fasting glucose and insulin were measured in each subject.
RESULTS
Among the 701 patients, 340 (48%) had NAFLD. The number of male patients was 490 (NAFLD+, 276; and NAFLD-, 214). The odds ratios for the prevalence of NAFLD increased according to the quartiles of the ApoB/A-I ratio (1.886, 2.245, and 2.587) (p<0.001).
CONCLUSIONS
The prevalence of NAFLD correlated with high ApoB/A-I ratio, suggesting that NAFLD increases the risk for atherosclerosis progression in male prediabetic patients.

Keyword

NAFLD; Apolipoprotein B; Apolipoprotein A-I; Prediabetes; Atherosclerosis

MeSH Terms

Apolipoprotein A-I
Apolipoproteins
Atherosclerosis
Cardiovascular Diseases
Cross-Sectional Studies
Fasting
Fatty Liver
Glucose
Humans
Insulin
Lipoproteins
Male
Odds Ratio
Prediabetic State
Prevalence
Apolipoprotein A-I
Apolipoproteins
Fatty Liver
Glucose
Insulin
Lipoproteins