Korean J Blood Transfus.
2015 Dec;26(3):316-322. 10.17945/kjbt.2015.26.3.316.
A Case of Washed Platelet Transfusion in a Patient with History of Recurrent Transfusion Reaction
- Affiliations
-
- 1Department of Laboratory Medicine, Center for Diagnostic Oncology, Hospital, National Cancer Center, Goyang, Korea. ksy@ncc.re.kr
- 2Hematology-Oncology Clinic, Center for Specific Organs, Hospital, National Cancer Center, Goyang, Korea.
- 3System Cancer Science, Graduate School of Cancer Science and Policy, Goyang, Korea.
- 4Department of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
- 5Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
- 6Translational Epidemiology Branch, Research Institute, National Cancer Center, Goyang, Korea.
- KMID: 2139797
- DOI: http://doi.org/10.17945/kjbt.2015.26.3.316
Abstract
- Anaphylactic transfusion reaction is caused by deficiency of certain protein(s) in the recipient. We report on the experience of platelet count recovery using washed platelets for transfusion in a patient who developed an anaphylactic transfusion reaction. A 50-year old male diagnosed with angioimmunoblastic T-cell lymphoma was treated with chemotherapy followed by autologous hematopoietic stem cell transplantation. Immediately after starting transfusion of apheresis platelets, he began sweating and complained of visual impairment, chest discomfort, and abdominal pain. Both systolic and diastolic blood pressures and oxygen saturation monitored by pulse oximetry were decreased. Platelet transfusion was discontinued immediately and hydrocortisone was administered, and the symptoms and signs were resolved within two hours. Laboratory test using post-transfusion blood showed no apparent evidence of hemolysis. Platelet washing procedure using normal saline three times was newly set to prevent anaphylactic reaction in the patient. Transfusions of washed platelets were performed 20 times for 60 days, and the patient showed no anaphylactic reaction during this period. He showed no evidence of immunoglobulin A, haptoglobin, C3, or C4 deficiencies. We confirmed that washed platelet transfusion is highly effective for prevention of anaphylactic transfusion reaction.
Keyword
MeSH Terms
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Abdominal Pain
Anaphylaxis
Blood Component Removal
Blood Group Incompatibility*
Blood Platelets*
Drug Therapy
Haptoglobins
Hematopoietic Stem Cell Transplantation
Hemolysis
Humans
Hydrocortisone
Immunoglobulin A
Lymphoma, T-Cell
Male
Oximetry
Oxygen
Platelet Count
Platelet Transfusion*
Sweat
Sweating
Thorax
Vision Disorders
Haptoglobins
Hydrocortisone
Immunoglobulin A
Oxygen
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