Korean J Blood Transfus.  2015 Dec;26(3):309-315. 10.17945/kjbt.2015.26.3.309.

A Case Report of Transfusion-Related Acute Lung Injury Induced in the Patient with HLA Antibody after Fresh Frozen Plasma Transfusion

• Chang KS
• Jun DW
• Kim Y
• Oh H
• Kang MK
• Lee J
• Moon I

• KMID: 2139796
• DOI: http://doi.org/10.17945/kjbt.2015.26.3.309

Abstract

Development of transfusion-related acute lung injury (TRALI), a non-cardiogenic pulmonary edema, after blood transfusion, is a rare but potentially leading cause of mortality from blood transfusion. We report on a case of TRALI in a 51-year male with acute calculous cholecystitis and liver cirrhosis. As preoperative treatment, he was given ten units of fresh frozen plasma (FFP) for 3 days before the operation. During the transfusion of the 10th unit of FFP, he experienced a sudden onset of hemoptysis, tachypnea, tachycardia, and cyanosis. Bilateral pulmonary infiltration not observed on the chest X-ray at the visit was newly developed. There was no evidence of volume overload but severe hypoxemia. Blood transfusion was stopped and he recovered fully after 8 days of oxygen therapy through a nasal cannula. Although HLA and HNA antibodies were not detected in the donor's blood, HLA antibodies (A2, B57, B58) were detected in the patient's blood. We reported this meaningful case of TRALI that occurred after transfusion of only fresh frozen plasma which did not contain human leukocyte antibody in a patient with HLA antibody.

Keyword

Transfusion-related acute lung injury (TRALI); Fresh frozen plasma (FFP); Anti-HLA antibody

MeSH Terms

Acute Lung Injury*
Anoxia
Antibodies
Blood Transfusion
Catheters
Cholecystitis
Cyanosis
Hemoptysis
Humans
Leukocytes
Liver Cirrhosis
Male
Mortality
Oxygen
Plasma*
Pulmonary Edema
Tachycardia
Tachypnea
Thorax
Antibodies
Oxygen