Nutr Res Pract.  2008 Dec;2(4):252-258. 10.4162/nrp.2008.2.4.252.

Effect of fructose or sucrose feeding with different levels on oral glucose tolerance test in normal and type 2 diabetic rats

• Kwon S
• Kim YJ
• Kim MK

• KMID: 2139200
• DOI: http://doi.org/10.4162/nrp.2008.2.4.252

Abstract

This study was designed to determine whether acute fructose or sucrose administration at different levels (0.05 g/kg, 0.1 g/kg or 0.4 g/kg body weight) might affect oral glucose tolerance test (OGTT) in normal and type 2 diabetic rats. In OGTT, there were no significant differences in glucose responses between acute fructose- and sucrose-administered groups. However, in normal rats, the AUCs of the blood glucose response for the fructose-administered groups tended to be lower than those of the control and sucrose-administered groups. The AUCs of the lower levels fructoseor sucrose-administered groups tended to be smaller than those of higher levels fructose- or sucrose-administered groups. In type 2 diabetic rats, only the AUC of the lowest level of fructose-administered (0.05 g/kg body weight) group was slightly smaller than that of the control group. The AUCs of fructose-administered groups tended to be smaller than those of the sucrose-administered groups, and the AUCs of lower levels fructose-administered groups tended to be smaller than those fed higher levels of fructose. We concluded from this experiment that fructose has tendency to be more effective in blood glucose regulation than sucrose, and moreover, that smaller amount of fructose is preferred to larger amount. Specifically, our experiments indicated that the fructose level of 0.05 g/kg body weight as dietary supplement was the most effective amount for blood glucose regulation from the pool of 0.05 g/kg, 0.1 g/kg and 0.4 g/kg body weights. Therefore, our results suggest the use of fructose as the substitute sweetener for sucrose, which may be beneficial for blood glucose regulation.

Keyword

Fructose; sucrose; oral glucose tolerance test

MeSH Terms

Animals
Area Under Curve
Blood Glucose
Body Weight
Dietary Supplements
Fructose
Glucose
Glucose Tolerance Test
Rats
Sucrose
Sweetening Agents
Blood Glucose
Fructose
Glucose
Sucrose
Sweetening Agents

Figure

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  Fig. 1 The changes in blood glucose concentration during an oral glucose tolerance test in SD rats

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  Fig. 2 The areas under the curve of the glucose response in SD rats

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  Fig. 3 The changes of blood glucose concentration during oral glucose tolerance test in GK rats

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  Fig. 4 The areas under the curve of the glucose response in GK rats

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