J Bacteriol Virol.  2014 Mar;44(1):112-114. 10.4167/jbv.2014.44.1.112.

cGAS-cGAMP Signaling and Antiviral Defense

• Manzoor Z
• Koh YS

• KMID: 2135365
• DOI: http://doi.org/10.4167/jbv.2014.44.1.112

Abstract

Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that plays an important role in innate immunity. Transfection of DNA or DNA virus infection results in the induction of type I interferon production in fibroblasts, macrophages, and dendritic cells which is dependent on cGAS. Recently, cGas (-/-) mice have been reported to be more vulnerable to fatal infection with herpes simplex virus 1 (HSV1) as compared to wild-type mice.

Keyword

Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS); Type I interferons; DNA sensor; Antiviral defense

MeSH Terms

Animals
Cytosol
Dendritic Cells
DNA
DNA Virus Infections
Fibroblasts
Guanosine
Herpesvirus 1, Human
Immunity, Innate
Interferon Type I
Macrophages
Mice
Transfection
DNA
Guanosine
Interferon Type I

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