Endocrinol Metab.  2012 Mar;27(1):31-38. 10.3803/EnM.2012.27.1.31.

Impact of Serum Adiponectin Concentration on Progression of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus

• Kim CS
• Park JR
• Yu SH
• Kang JG
• Ryu OH
• Lee SJ
• Hong EG
• Kim DM
• Yoo JM
• Ihm SH
• Choi MG
• Yoo HJ

• KMID: 2134815
• DOI: http://doi.org/10.3803/EnM.2012.27.1.31

Abstract

BACKGROUND
Increased cardiovascular events, which is the leading cause of death in type 2 diabetic patients, are mainly caused by accelerated atherosclerosis. Adiponectin has been suggested as a risk factor for cardiovascular diseases in cross-sectional studies. However, little is known about the impact of adiponectin on the progression of carotid atherosclerosis in type 2 diabetic patients. This study was conducted to evaluate the impact of early adiponectin levels on the progression of carotid atherosclerosis.
METHODS
From March 2009, 150 patients with type 2 diabetes were consecutively enrolled in our affiliated outpatient clinic. Anthropometric and biochemical data, including adiponectin levels, were measured in each participant. We measured the carotid intima-media thickness (CIMT) at baseline and at 1-year follow-up (n = 111). Then, we prospectively studied the relationship between the serum adiponectin levels and the progression of CIMT for 1 year.
RESULTS
Adiponectin levels negatively correlated with CIMT (r = -0.219, P = 0.015). Moreover, mean progression of CIMT was 0.016 +/- 0.040 mm. However, there was no correlation between adiponectin levels and the progression of CIMT within 1-year follow-up period (r = -0.156, P = 0.080). Age (beta = 0.556, P = 0.004), LDL cholesterol (beta = 0.276, P = 0.042), and A1C (beta = 0.309, P = 0.038) were found to be independent risk factors for CIMT. However, A1C (beta = 0.311, P = 0.042) was found to be the only independent risk factor for the progression of CIMT.
CONCLUSION
In our study, adiponectin levels were negatively associated with CIMT. However, it did not affect the progression of CIMT at 1-year follow-up. Overall glycemic control is the most important factor in the progression of CIMT in patients with type 2 diabetes.

Keyword

Adiponectin; Carotid atherosclerosis; Carotid intima media thickness; Type 2 diabetes mellitus

MeSH Terms

Adiponectin
Ambulatory Care Facilities
Atherosclerosis
Cardiovascular Diseases
Carotid Artery Diseases
Carotid Intima-Media Thickness
Cause of Death
Cholesterol, LDL
Diabetes Mellitus, Type 2
Follow-Up Studies
Humans
Prospective Studies
Risk Factors
Adiponectin
Cholesterol, LDL

Figure

• 

  Fig. 1 Correlation between serum adiponectin concentration (log transformed) and baseline carotid artery intima-media thickness (CIMT). (r = -0.219, P = 0.015).

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  Fig. 2 Correlation between serum adiponectin concentration (log transformed) and progression of carotid artery intima-media thickness (CIMT) (r = -0.156, P = 0.080).

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