Chonnam Med J.  2004 Sep;40(3):158-160.

A Case Report of Acute Transient Encephalopathy Induced by Low Dose Baclofen

• Ryu HC
• Lim JS
• Cho KY
• Choi SM

Abstract

Baclofen has been reported to elicit various neurologic complications, such as encephalopathy, respiratory depression, muscular hypotonia and generalized hyporeflexia, especially with excessive doses. However, acute encephalopathy caused by low-dose baclofen has rarely been reported. We report a case of acute transient encephalopathy with mental deepening and unilateral myoclonic jerk caused by low- dose baclofen. Brain MRI showed no lesions except previous pontine infarction and laboratory findings were within normal limits. The clinical abnormalities improved shortly after baclofen was discontinued.

Keyword

Baclofen; Encephalopathy; Myoclonus

MeSH Terms

Baclofen*
Brain
Infarction
Magnetic Resonance Imaging
Muscle Hypotonia
Myoclonus
Reflex, Abnormal
Respiratory Insufficiency
Baclofen