Tuberc Respir Dis.
2005 Jan;58(1):78-82. 10.4046/trd.2005.58.1.78.
A Case of Propylthiouracil Induced Diffuse Pulmonary Hemorrhage
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea. jaejshim@kumc.or.kr
- KMID: 2132204
- DOI: http://doi.org/10.4046/trd.2005.58.1.78
Abstract
- Propylthiouracil(PUT) is a drug which used at Grave's disease. But PTU has recently been observed to associated with antineutrophil cytoplasmic antibody(ANCA)-positive vasculitis resulting in, infrequently, diffuse alveolar he?morrhage. We report the case of a patient who developed diffuse pulmonary hemorrhage after she had been taking PTU for two years. She had received a diagnosis of Grave's disease at two years ago. The serologic study was positive for ANCA with myeloperoxidase(MPO) specificity. Bronchoalveloar lavage(BAL) fluid analysis revealed hemosiderin- laden macrophages. Such findings suggested propylthiouracil?induced dffuse pulmonary hemorrhage associated with antineutrophil cytoplasmic antibody. To our knowledge, this represents the first documentation in a case of PTU-induced diffuse pulmonary hemorrhage in Korea.
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