J Korean Radiol Soc.
2007 May;56(5):479-481. 10.3348/jkrs.2007.56.5.479.
Propylthiouracil-induced Diffuse Pulmonary Hemorrhage: A Case Report with the Clinical and Radiologic Findings
- Affiliations
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- 1Department of Radiology, Sanggye Paik Hospital, Inje University College of Medicine, Korea. kjsrad@sanggyepaik.ac.kr
- 2Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Korea.
- KMID: 2024513
- DOI: http://doi.org/10.3348/jkrs.2007.56.5.479
Abstract
- Propylthiouracil (PTU) is a drug that's used to manage hyperthyroidism and it can, on rare occasions, induce antineutrophil cytoplasmic antibody-associated vasculitis that involves multiple organ systems and it can also cause extremely rare isolated or diffuse pulmonary hemorrhage. We report here on a case of a patient who developed diffuse pulmonary hemorrhage after she had been taking PTU for five years. The patient is a 33-year-old woman who presented with hemoptysis. Simple chest radiographs and the chest CT showed bilateral ground-glass opacity, consolidation and pulmonary arterial hypertension. The bronchoalveolar lavage fluid revealed alveolar hemorrhage. The laboratory values showed increased perinuclear-antineutrophil cytoplasmic antibody (p-ANCA) and anti-peroxidase antibody titers.
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