The Resistance to Ciprofloxacin in Bacterial Ocular Disease

Kim, Do Gyun; Jin, Kyung Hyun

Abstract

PURPOSE: To evaluate the change of the sensitivity and resistance to ciprofloxacin of isolates in bacterial ocular disease, bacterial keratitis and conjunctivitis.
METHODS
From January 1992 to December 1999 in KyungHee Medical Center, we carried out direct smear and culture from conjunctiva and cornea and studied retrospectively.
RESULTS
A total of 420 bacteria and fungi were isolated and 39 strains were identified. Antibiotic sensitivity test was done in isolated bateria and fungi. Gram-positive bacteria accounted for 324 of all bacteria, gram-negative organisms for 81 in isolated causative organisms. Major causative organisms of bacterial ocular disease, bacterial keratitis and conjunctivitis are coagulase-negative staphylococcus, Staphylococcus aureus, Pseudomonas aeruginosa in that order. Among 420 isolates, 405 bacteria and 15 fungi was isolated. In vitro examination for susceptibility and resistance of causative organisms to ciprofloxacin was done in 67 of 420 isolates. Of the 67 isolates, 57 were sensitive to ciprofloxacin and 10 were resistant to ciprofloxacin. All resistant cases to ciprofloxacin was 2 cases in 1994, 7 cases in 1998, and 1 case in 1999.
CONCLUSIONS
The resistance to ciprofloxacin has a increasing tendency. Therefore, ciprofloxacin should be used carefully, when used for prevention of infection and primary treatment in mild ocular diseases.