Lab Anim Res.  2010 Dec;26(4):361-367. 10.5625/lar.2010.26.4.361.

Dangyuja (Citrus grandis Osbeck) Peel Improves Lipid Profiles and Alleviates Hypertension in Rats Fed a High-Fat Diet

• Hong HJ
• Jin JY
• Yang H
• Kang WY
• Kim DG
• Lee S
• Choi Y
• Kim JH
• Han CH
• Lee YJ

• KMID: 2114704
• DOI: http://doi.org/10.5625/lar.2010.26.4.361

Abstract

Obesity is a major public health problem and significant risk factor for many serious diseases including coronary artery disease, cancer, and diabetes. This study was performed to investigate the hypolipidemic effects and anti-hypertensive effect of Dangyuja (Citrus grandis Osbeck) peel, which is bred on Jeju island, in rats fed a high-fat diet. This study was conducted on 4 equal rat groups which were fed as follows; normal diet group (ND), high fat diet group (HFD), high fat diet supplemented with powdered peel of Dangyuja (1%, wt/wt) group (HFD+Dangyuja), and high fat diet treated with sibutramine simultaneously at a dose of 10 mg/kg group (HFD+Sibutramine). After feeding the high fat diet, body weight gain and relative weight of adipose tissues and liver significantly increased in HFD group, but Dangyuja peel supplementation protected these HFD-induced changes. The levels of serum triglyceride, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and the atherogenic index significantly decreased in the HFD+Dangyuja peel group compared with the HFD group. The systolic blood pressure was significantly increased by feeding the high fat diet, whereas the supplementation of Dangyuja peel effectively prevented the elevation of blood pressure. Therefore, these results suggest that Dangyuja exerts a beneficial effect on obesity by improving lipid metabolism and alleviating obesity-related hypertension.

Keyword

Dangyuja; high-fat diet; obesity; cholesterol; hypertension

MeSH Terms

Animals
Blood Pressure
Body Weight
Cholesterol
Coronary Artery Disease
Cyclobutanes
Diet
Diet, High-Fat
Hypertension
Lipid Metabolism
Lipoproteins
Liver
Obesity
Public Health
Rats
Risk Factors
Cholesterol
Cyclobutanes
Lipoproteins

Figure

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  Figure 1. Effects of peel of Dangyuja on relative organ and fat weights of high-fat diet (HFD)-fed rats. ++P<0.01, +++P<0.001 compared to normal diet (ND) group. ∗∗P<0.01, ∗∗∗P<0.001 compared to HFD group.

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  Figure 2. Effects of peel of Dangyuja on serum lipid contents of high-fat diet (HFD)-fed rats. LDL; low-density lipoprotein, HDL; high-density lipoprotein. +P<0.05, +++P<0.001 compared to normal diet (ND) group. ∗P<0.05, ∗∗P<0.01 compared to HFD group.

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  Figure 3. Effect of peel of Dangyuja on atherogenic index of high-fat diet (HFD)-fed rats. ++P<0.01 compared to normal diet (ND) group. ∗P<0.05 compared to HFD group.

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  Figure 4. Effect of peel of Dangyuja on hepatic malondialdehyde (MDA) level of high-fat diet (HFD)-fed rats. +++P<0.001 compared to normal diet (ND) group. ∗∗P<0.01, ∗∗∗P<0.001 compared to HFD group.

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  Figure 5. Effect of peel of Dangyuja on systolic blood pressure of high-fat diet (HFD)-fed rats. +++P<0.001 compared to normal diet (ND) group. ∗∗P<0.01 compared to HFD group.

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  Figure 6. Effect of peel of Dangyuja on accumulation of lipid droplets in the liver of high-fat diet (HFD)-fed rats. A; normal diet group, B; HFD group, C; HFD+Dangyuja, D; HFD+Sibutramine. Original magnification=X200.

Reference

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