J Korean Pediatr Soc.  1999 Feb;42(2):257-263.

Diagnostic Utility of D-dimer Test in Disseminated Intravascular Coagulation with Sepsis

• Kim JE
• Hong YM
• Kim GH

Abstract

PURPOSE: Disseminated intravascular coagulation(DIC) is a confusing disorder from both a diagnostic and therapeutic standpoint. In order to investigate the effectiveness of D-dimer test in disseminated intravascular coagulation associated with sepsis, D-dimer level and other laboratory tests were performed.
METHODS
Fifty patients with disseminated intravascular coagulation associated with sepsis, who were admitted to the department of pediatrics, were evaluated by several tests(total WBC, erythrocyte sedimentation rate, C-reactive protein, blood culture test, prothrombin time, partial thromboplastin time, fibrinogen, fibrin degradation product, and D-dimer). If the test showed abnormal, follow-up study was performed.
RESULTS
The positive rate of D-dimer in DIC was 72% and FDP 58%. The false positive rate of D-dimer level in normal children was 3.3% and FDP 6.7%. There was a significant linear correlation between D-dimer and FDP.
CONCLUSION
D-dimer test was the most effective test for diagnosing disseminated intravascular coagulation.

MeSH Terms

Blood Sedimentation
C-Reactive Protein
Child
Dacarbazine
Disseminated Intravascular Coagulation*
Fibrin
Fibrinogen
Follow-Up Studies
Humans
Partial Thromboplastin Time
Pediatrics
Prothrombin Time
Sepsis*
C-Reactive Protein
Dacarbazine
Fibrin
Fibrinogen