J Korean Soc Pediatr Nephrol.  2003 Oct;7(2):245-252.

A Case of Posttransplant Lymphoproliferative Disease Following Renal Transplantation in a Child

• Jhang WK
• Hahn H
• Lee MJ
• Park YS
• Ghim TT

Abstract

Posttransplant lymphoproliferative disease(PTLD) has emerged as a potential life-threatening complication of immunosuppressive therapy after organ transplantation. The occurrence of PTLD is usually associated with an Epstein-Barr virus(EBV) infection in patients who are treated by aggressive immunosuppressive therapy. PTLD is represented by diverse manifestations ranging from reactive lymphoid hyperplasia to high grade malignant lymphoma. This is a case report of a late PTLD in a child. The patient is a 14-year-old girl, who presented as malignant lymphoma 44 months after successful renal transplantation. There was no evidence of EBV infection. On bone marrow study, many neoplastic lymphoid cells were detected. Aggressive chemotherapy for PTLD had resulted in clinical remission. However the patient expired from uncontrolled sepsis and septic shock after 77 days.

Keyword

Posttransplant lymphoproliferative disease; EBV; Late-onset; Malignant lymphoma; Kidney transplantation

MeSH Terms

Adolescent
Bone Marrow
Child*
Drug Therapy
Epstein-Barr Virus Infections
Female
Herpesvirus 4, Human
Humans
Kidney Transplantation*
Lymphocytes
Lymphoma
Organ Transplantation
Pseudolymphoma
Sepsis
Shock, Septic
Transplants