J Korean Soc Pediatr Nephrol.  2002 Apr;6(1):123-130.

A Case of Posttransplant Lymphoproliferative Disease (PTLD) Following Renal Transplantation in a Child

• Eun BW
• Park ES
• Lee SY
• Hahn HW
• Jang JY
• Park KM
• Kim CW
• Kang GH
• Ko JS
• Ha IS
• Lee HJ
• Cheong HI
• Seo JK
• Choi Y

Abstract

Posttransplant lymphoproliferative disease (PTLD) represents a diverse lymphoproliferative disorder ranging from nonspecific reactive hyperplasia to malignant immunoblastic sarcoma developed in a setting of immunosuppression following organ or cellular transplantation. It is often associated with Epstein-Barr virus (EBV) infection and high dose immunosuppression. PTLD after renal transplantation was reported at first in adult in Korea in 1997. In children there have been several cases of PTLD after liver transplantation but PTLD after renal transplantation has not been reported. This is a case report of PTLD developed 4 months after renal transplantation in a 9-year-old boy. The major clinical manifestations were fever, multiple lymph nodes enlargement and blood-tinged stool. EBV was detected by in-situ hybridization in the enlarged cervical lymph node and the colonic tissue. Histological examination revealed B-cell lineage. Use of ganciclovir and reduction of the immunosuppression level resulted in complete remission of PTLD. This is the first pediatric case report of PTLD following renal transplantation in Korea.

Keyword

Posttransplant lymphoproliferative disorder; Renal transplantation; Child

MeSH Terms

Adult
B-Lymphocytes
Child*
Colon
Fever
Ganciclovir
Herpesvirus 4, Human
Humans
Hyperplasia
Immunosuppression
Kidney Transplantation*
Korea
Liver Transplantation
Lymph Nodes
Lymphoma, Large-Cell, Immunoblastic
Lymphoproliferative Disorders
Male
Ganciclovir