J Korean Soc Ther Radiol Oncol.  2000 Sep;18(3):187-193.

The Correlation between DNA Ploidy and the Clinicohistologic Findings in Colorectal Cancer

• Lee SH
• Kim HJ
• Kim WC
• Cho YK
• Loh JK
• Woo ZH
• Hwang TS

Abstract

PURPOSE
DNA ploidy pattern was shown to correlate with several clinicohistologic findings in several tumors. Aim of this study was to evaluate the correlation of the clinicohistologic findings in colorectal cancer and the failure pattern in rectosigmoid cancer with DNA ploidy.
MATERIALS AND METHODS
DNA flow cytometry using the Hedley methods on paraffin embedded specimen from 117 patients with colorectal cancers after curative resection was performed. We tried to find the correlation between DNA ploidy and various clinicohistologic findings. And then the correlation DNA ploidy and the failure pattern in 75 patients of rectosigmoid cancer was analized.
RESULTS
Forty samples (34.2%) from tumors gave aneuploidy histogram. There was no significant difference in the frequency of DNA aneuploidy in terms of age, sex, depth of invasion, location and Dukes stage. But there was a significant correlation between DNA ploidy and the failure rates in Dukes stage B rectosigmoid cancer ( p=0.048).
CONCLUSIONS
These findings suggest that DNA ploidy pattern shows the correlation with the treatment failure rates in Dukes stage B rectosigmoid, but not with many other clinicohistologic findings. However, more patients will be needed to disclose these findings.

Keyword

Colorectal cancer; DNA ploidy

MeSH Terms

Aneuploidy
Colorectal Neoplasms*
DNA*
Flow Cytometry
Humans
Paraffin
Ploidies*
Treatment Failure
DNA
Paraffin