J Korean Surg Soc.  1997 Apr;52(4):606-614.

Perioperative Studies of Folcal & Diffuse Type Nesidioblastosis in Adult: 2 case report

• Yang KS
• Chai KM
• Yun KJ

Abstract

Nesidioblastosis is a term that describes the prolonged differentiation of the Langerhan's islet cells from the epithelium of the pancreatic duct. Islet cell lesions accompanied with hyperinsulinemic, 80% are found to be benign islet cell tumors. In additional 10% are malignant and the remaining are nesidioblastosis. Children are usually affected and develop hyperinsulinemic hypoglycemia, but it is rare in adults. Only 20 cases has been reported worldwide and 6 cases in Korea. A 41-year old man & 42-year old woman was admitted due to intermittent hypoglycemic symptoms, that had been relieved by carbohydrate ingestion. Hyperinsulinemic hypoglycemia was documented during prolonged fasting. Under the presumptive diagnosis of insulinoma, Abdominal CT, Celiac angiogram and percutaneous transhepatic portal venous sampling were done, but we could not find any definitive mass. 85% of the pancreas & 88% of the pancreas was removed respectively. Pathologic examination of the resected pancreas revealed irregularly sized islets and scattering of small endocrine cell clusters throughout the acinar tissue and ductuloinsular complex.

Keyword

Nesidioblastosis; Hyperinsulinemic hypoglycemia

MeSH Terms

Adenoma, Islet Cell
Adult*
Child
Diagnosis
Eating
Endocrine Cells
Epithelium
Fasting
Female
Humans
Hypoglycemia
Insulinoma
Islets of Langerhans
Korea
Nesidioblastosis*
Pancreas
Pancreatic Ducts
Tomography, X-Ray Computed