Korean J Hepatobiliary Pancreat Surg.
2008 Dec;12(4):302-306.
A Case of Surgical Treatment of Nesidioblastosis with Hyperinsulinemic Hypoglycemia in an Adult
- Affiliations
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- 1Department of Surgery, College of Medicine Pochon CHA University, Sungnam, Korea. wehrwolf@cha.ac.kr
- 2Department of Pathology, College of Medicine Pochon CHA University, Sungnam, Korea.
- 3Department of Endocrinology, College of Medicine Pochon CHA University, Sungnam, Korea.
Abstract
- Nesidioblastosis is a rare disorder, and it usually considered as a cause of neonatal hyperinsulinemic hypoglycemia. A 35 year-old-woman with hyperinsulinemic hypoglycemia was admitted in an unconscious condition. Abdominal CT, pancreas MRI and celiac angiography with an intra-arterial calcium stimulation test revealed a suspicious insulin-producing tumorous lesion in the head of pancreas. The patient underwent enucleation of the pancreas head tumor under the initial diagnosis of insulinoma. However, the tumor was confirmed histologically as nesidioblastosis that showed ductoendocrine proliferations and numerous small endocrine cell groups. Nesidioblastosis is classified into a focal type and a diffuse type, which are characterized by different clinical outcomes. The patient in our case showed a normal blood glucose level after operation, which is often the case for the focal type. Herein, we report this very rare case of adult nesiodioblastosis that was successfully treated by surgical resection.
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