J Korean Soc Traumatol.
2013 Mar;26(1):6-13.
Sulforaphane Post-treatment Had No Protective Effects in Paraquat-intoxicated Rats
- Affiliations
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- 1Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonnggi-do, Korea. hyukmd@gmail.com
- 2Department of Pathology, Seoul National University Hospital, Seoul, Korea.
Abstract
- PURPOSE
Sulforaphane is a naturally-occurring isothiocyanate abundant in broccoli. It has been suggested as a promising antioxidant. In this study, the therapeutic effect of sulforaphane in paraquat intoxication was investigated.
METHODS
Paraquat was administered via the tail vein, after which sulforaphane or a vehicle (4% DMSO) was administered intraperitoneally 15 minutes after paraquat administration. Histological injury, lipid peroxidation, plasma cytokine (IL-6, IL-10), and nitric oxide were measured. In addition, the effect of sulforaphane on survival in paraquat-intoxication was observed.
RESULTS
Regarding histological injury, lipid peroxidation, and plasma cytokine and nitric-oxide response, sulforaphane administration showed no protective effects in paraquat-intoxicated rats. Rather, it increased mortality (log rank p=0.03) and caused lipid peroxidation, as well as plasma cytokine and nitric-oxide production, to be increased.
CONCLUSION
Sulforaphane had no therapeutic effect on paraquat-intoxicated rats; rather, it increased mortality.
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