- Sulforaphane Post-treatment Had No Protective Effects in Paraquat-intoxicated Rats
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Jang GS, Lee JH, Kim K, Jo YH, Rhee JE, Lee K, Park CJ, Kang CW, Lee S, Kim J
- KMID: 2094364
- J Korean Soc Traumatol.
- 2013 Mar;26(1):6-13.
PURPOSE: Sulforaphane is a naturally-occurring isothiocyanate abundant in broccoli. It has been suggested as a promising antioxidant. In this study, the therapeutic effect of sulforaphane in paraquat intoxication was investigated. METHODS:... -
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- Effects of the Antioxidant Sulforaphane on Hyperlocomotion and Prepulse Inhibition Deficits in Mice after Phencyclidine Administration
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Shirai Y, Fujita Y, Hashimoto
- KMID: 2171215
- Clin Psychopharmacol Neurosci.
- 2012 Aug;10(2):94-98.
OBJECTIVE: Accumulating evidence suggests that oxidative stress plays a role in the pathophysiology of schizophrenia and that the potent antioxidants may be potential therapeutic drugs for schizophrenia. This study was... -
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- Inactivation of Aconitase by Tetrahydrobiopterin in DArgic Cells: Relevance to PD
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Yoon NS, Cho Y, Lee SY, Choi HJ, Hwang O
- KMID: 2165316
- Exp Neurobiol.
- 2010 Jun;19(1):23-29.
- doi: 10.5607/en.2010.19.1.23
Oxidative damage is thought to be a major cause of the progression of dopamine (DA)rgic neurodegeneration as in Parkinson's disease. We have previously reported that tetrahydrobiopterin (BH4), an endogenous molecule... -
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- Antidotes of cyanide intoxication
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Lee SW, Kim JS
- KMID: 1783722
- J Korean Med Assoc.
- 2013 Dec;56(12):1076-1083.
- doi: 10.5124/jkma.2013.56.12.1076
Cyanide poisoning can occur from industrial disasters, smoke inhalation from fire, food, and multiple other sources. Cyanide inhibits mitochondrial oxidative phosphorylation by blocking mitochondrial cytochrome oxidase, which in turn results... -
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- Comparison of the Antioxidant Effects of Diallyl Sulfide, Capsaicin, Gingerol and Sulforaphane in H2O2-Stressed HepG2 Cells
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Lee S, Wi H, Lee M
- KMID: 2268609
- Korean J Nutr.
- 2011 Dec;44(6):488-497.
- doi: 10.4163/kjn.2011.44.6.488
Oxygen is necessary to sustain life, yet cellular oxygen metabolism creates destructive elements called free radicals. Free radicals are chemically unbalanced and carrying free electrons that can damage molecules, potentially... -
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- Sulforaphane Induces Antioxidative and Antiproliferative Responses by Generating Reactive Oxygen Species in Human Bronchial Epithelial BEAS-2B Cells
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Lee YJ, Lee SH
- KMID: 1123448
- J Korean Med Sci.
- 2011 Nov;26(11):1474-1482.
- doi: 10.3346/jkms.2011.26.11.1474
Sulforaphane (SFN) is a naturally occurring compound which is known to induce the phase II antioxidant genes via Nrf2 activation, although the underlying mechanism has not been fully elucidated. In... -
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