Korean J Anesthesiol.  2000 Jan;38(1):14-19. 10.4097/kjae.2000.38.1.14.

The Effect of Propofol on Blood Pressure and Heart Rate during Induction of Anesthesia and Endotracheal Intubation in Patients with Sinus Bradycardia

• Lim HK
• Chung CK
• Han JU
• Song JH
• Cha YD
• Park DH
• Shinn HK
• Kim TJ

• KMID: 2091482
• DOI: http://doi.org/10.4097/kjae.2000.38.1.14

Abstract

BACKGROUND: Bradycardia frequently occurs in intravenous anesthesia with propofol. Patients with sinus bradycardia have increased vagal tone at rest. The purpose of this study is to evaluate the effect of propofol on blood pressure and heart rate during induction of anesthesia in patients with sinus bradycardia.
METHODS
Sixteen adult patients were studied. No anticholinergics were used before induction. Anesthesia was induced intravenously with midazolam 0.03 mg/kg, propofol 2 mg/kg, lidocaine 1 mg/kg and vecuronium 0.12 mg/kg. Anesthesia was maintained with continuous infusion of propofol 150 microgram/ kg/min and 100% O2. Hemodynamic data were recorded 3 minutes after midazolam injection, immediately after propofol injection, 1 and 2 minutes after propofol continuous infusion, and immediately, 1, 3 and 5 minutes after intubation.
RESULTS
Heart rate significantly increased after intravenous injection of propofol (P < 0.05) and was maintained during the study. There was no incidence of bradycardia.
CONCLUSIONS
Anesthesia induction and maintenance with propofol could be a suitable and safe ansethetic method for patients with sinus bradycardia.

Keyword

Anesthetic, intravenous: propofol; Anesthetic techniques: intravenous; Heart: blood pressure; bradycardia; heart rate

MeSH Terms

Adult
Anesthesia*
Anesthesia, Intravenous
Blood Pressure*
Bradycardia*
Cholinergic Antagonists
Heart Rate*
Heart*
Hemodynamics
Humans
Incidence
Injections, Intravenous
Intubation
Intubation, Intratracheal*
Lidocaine
Midazolam
Propofol*
Vecuronium Bromide
Cholinergic Antagonists
Lidocaine
Midazolam
Propofol
Vecuronium Bromide