Anesthetic Induction with Single Bolus Doses of Propofol

Park, Gyung Hee; Cho, Nam Soo; Chung, Jong Dal

Abstract

Propofol, by virtue of its favorable pharmacokinetic profile, has already achieved considerable popularity for induction and maintenance of anesthesia for short duration surgery. Short acting opioids are often used as part of balanced technique. Because of their similar pharmacodynamic characteristics(rapid onset and short duration of action), it seems that propofol and fentanyl would be a adequate complementary agents for total intravenous anesthesia when used in combination. The purpose of present study was to access the effect of fentanyl on the changes hemodynamic and respiratory responses when used in combination with propofol. Eighty patients of ASA grade l or 2 scheduled to undergo minor gynecological, abdominal and orthopedic procedures were allocated randomly to 4 groups. Group A, C was induced with pentothal sodium or propofol alone respectively and maintained using 60% nitrous oxide in oxygen. Cardiovascular and respiratory parameters were checked before induction, and 2, 4, 6, 8 minutes after injection. The results were as follows 1) Changes in mean arterial pressur, after 2 minutes were more significantly decreased in propofol with fentanyl group than propofol alone. 2) Changes in heart rate Minimal changes in propofol group, but showed significantly decrease in propofol-fentanyl group. 3) Resipiratory changes Propofol-fentanyl group produce a more frequent, long standing apnea than other group. 4) Side effect Excitatory effects, and pain on injection were more frequent in propofol group than pentothal sodium group. Nausea, vomiting were more frequent in pentothal sodium group than propofol group.