Korean J Lab Med.
2002 Oct;22(5):295-298.
Four Cases of Myelodysplastic Syndrome with Systemic Lupus Erythematosus
- Affiliations
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- 1Department of Laboratory Medicine, College of Medicine, Catholic University, Korea. sgkim@cataegu.ac.kr
- 2Department of Internal Medicine, College of Medicine, Catholic University, Korea.
- 3Department of Internal Medicine, Fatima Hospital, Daegu, Korea.
Abstract
- Systemic lupus erythematosus (SLE) has been a well-known systemic autoimmune disease with hematologic abnormalities such as anemia, leukopenia, and thrombocytopenia. Myelodysplastic syndrome (MDS) is defined as a clonal expansion of BM derived pluripotent stem cells. Although SLE and MDS are independent disease entities, there have been several reports regarding rheumatic manifestations of MDS, which suggest that there might be a relationship between these two diseases in the pathogenetic sequence. We reviewed our cases of MDS and SLE and encountered four patients with both MDS and SLE, both of which developed concurrently. They were all women from 15 to 50 years old. They had anemia or pancytopenia. Bone marrow findings were disclosed as MDS, RA or hypoplastic MDS, RA. They had positive ANA at a titer above 1:160 of homogeneous, speckled, or dense cytoplasmic pattern. Double-stranded DNA levels increased in all cases, whereas serum complement and immunoglobulin levels were decreased except in case 1.
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