Korean J Med.  2002 Jul;63(1):98-102.

A case of MALT lymphoma of the urinary bladder

• Lee JY
• Kim WS
• Song SY
• Lee SI
• Park JO
• Kim KH
• Ko YH
• Ree HJ
• Jung CW
• Im YH
• Kang WK
• Lee HG
• Park CH
• Park KC

Abstract

Primary lymphoma of the urinary bladder is a rare non-epithelial bladder tumor accounting for less than 1% of all bladder tumors. Approximately 17 cases of MALT lymphomas of bladder have been reported in the literature. Most reported MALT lymphomas of bladder have a female sexual preponderance with a mean age of 58 years with common presenting symptoms of hematuria, dysuria and urinary frequency. The reported prognosis of MALT lymphoma of the urinary bladder is excellent. We report a case of MALT lymphoma of urinary bladder in a 57-year-old woman patient who presented with a two-year history of persistent dysuria and urinary frequency. An intravenous pyelogram and cystoscopy revealed a 1 cm focal elevated lesion at the base of urinary bladder. The tissue obtained by transurethral resection (TUR) showed plasma cell infiltration consistent with low grade marginal zone B cell lymphoma. The immunohistochemical studies showed an immunoglobulin restriction to lambda light chain while the nested polymerase chain reaction analysis of the tissue showed a monoclonal Ig heavy-chain gene rearrangement. The clinical staging protocol revealed that the tumor was primarily arising from the urinary bladder with no evidence of other site involvements. The patient received radiation therapy of 3060 cGy in 17 fractions.

Keyword

Lymphoma; Mucosa-Associated Lymphoid Tissue; Bladder

MeSH Terms

Cystoscopy
Dysuria
Female
Gene Rearrangement
Hematuria
Humans
Immunoglobulins
Lymphoma
Lymphoma, B-Cell, Marginal Zone*
Middle Aged
Plasma Cells
Polymerase Chain Reaction
Prognosis
Urinary Bladder Neoplasms
Urinary Bladder*
Immunoglobulins