Korean J Med.  2014 Aug;87(2):229-233. 10.3904/kjm.2014.87.2.229.

A Case of Complete Remission of Mucosa-associated Lymphoid Tissue Lymphoma of the Urinary Bladder after Eradication of Helicobacter Pylori

• Lee S
• Choo MS
• Ryu MH
• Song M
• Seo S
• Jeong Y
• Seo M
• Huh J

• KMID: 1710037
• DOI: http://doi.org/10.3904/kjm.2014.87.2.229

Abstract

Primary lymphoma of the urinary bladder is rare, comprising 0.2% of extranodal lymphomas. The predominant subtype of mucosa-associated lymphoid tissue (MALT) is extranodal marginal zone lymphoma. We report a case of MALT lymphoma of the urinary bladder in a 53-year-old female patient presenting with a five-year history of persistent hematuria and urinary frequency. A cystoscopy revealed multiple nodular lesions at the posterior wall and trigone of the bladder. The tissue obtained by cold-cup biopsy revealed lymphoid infiltration consistent with low-grade MALT lymphoma. Image studies revealed that the tumor originated from the urinary bladder and there was no evidence of metastases. The patient was positive for a rapid urease test. Because of the relationship between gastric MALT lymphoma and Helicobacter pylori, the patient was treated with antibiotics to eradicate Helicobacter pylori. The lymphoma subsequently disappeared and the patient has remained in persistent complete remission for eight years.

Keyword

Urinary Bladder; Lymphoma; Mucosa-associated Lymphoid Tissue; Helicobacter pylori; Antibiotics

MeSH Terms

Anti-Bacterial Agents
Biopsy
Cystoscopy
Female
Helicobacter pylori*
Hematuria
Humans
Lymphoid Tissue
Lymphoma
Lymphoma, B-Cell, Marginal Zone*
Middle Aged
Neoplasm Metastasis
Urease
Urinary Bladder*
Anti-Bacterial Agents
Urease