Korean J Nephrol.  2011 May;30(3):310-314.

A Case of Biopsy-Proven Acute Tubular Necrosis Associated with Vancomycin Overdose

Affiliations
  • 1Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea. hyekim@chungbuk.ac.kr
  • 2Department of Pathology, Chungbuk National University College of Medicine, Cheongju, Korea.

Abstract

Vancomycin has been associated with acute kidney injury, particularly in the concomitant treatment with aminoglycoside or in the presence of other risk factor such as preexisting renal disease, sepsis, or hemodynamic instability. Vancomycin-related nephrotoxicity typically manifests as acute tubulointerstitial nephritis. Biopsy-proven acute tubular necrosis associated with vancomycin intoxication in the absence of aminoglycoside has been reported only in very few cases. We report a case of biopsy-proven acute tubular necrosis associated with vancomycin intoxication that was treated by continuous venovenous hemodiafiltration. A 28-year-old male without preexisting renal disease received a massive overdose of vancomycin. The plasma vancomycin level was 440.3 microg/mL. Renal biopsy revealed acute tubular necrosis that there is marked thinning of the tubular epithelium with dilatation of the tubular lumens and severe foamy epithelial cell changes in tubules. Continuous venovenous hemodiafiltration resulted in efficient reduction of serum vancomycin levels, which was followed clinically by recovered of renal function.

Keyword

Vancomycin; Acute kidney tubular necrosis; Hemodiafiltration

MeSH Terms

Acute Kidney Injury
Adult
Biopsy
Dilatation
Epithelial Cells
Epithelium
Hemodiafiltration
Hemodynamics
Humans
Kidney Tubular Necrosis, Acute
Male
Necrosis
Nephritis, Interstitial
Plasma
Risk Factors
Sepsis
Vancomycin
Nephritis, Interstitial
Vancomycin
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