Korean J Nephrol.  2005 Jan;24(1):26-31.

Effects of Renin-angiotensin System Blockade on Tubulointerstitial Lesions in Adriamycin-induced Nephropathy

Affiliations
  • 1Department of Internal Medicine, Hanyang University, Guri Hospital, Guri, Korea. kimhj@hanyang.ac.kr
  • 2Department of Pathology, Hanyang University College of Medicine, Seoul, Korea.
  • 3Department of Physiology, Chonnam National University Medical School, Gwangju, Korea.

Abstract

PURPOSE
Effects of renin-angiotensin system blockade on tubulointerstitial lesions were examined in adriamycin-induced nephropathy. METHODS: Male Sprague-Dawley rats were used. The three experimental groups were intravenously injected with adriamycin (2 mg/kg). After 6 weeks, rats showing heavy proteinuria were orally treated with either cilazapril 1 mg/kg/day (ACEi group, n=7) or losartan 10 mg/kg/day (ARB group, n=7) during the period of additional 6 weeks. The other group was maintained without any drugs (ADR group, n=6). The control group was without adriamycin treatment and maintained during the 12 weeks (Control, n=5). RESULTS: Systolic blood pressure was increased following the adriamycin treatment, which was normalized by treatment with cilazapril or losartan. Accordingly, cilazapril and losartan normalized the 24-h urine protein/creatinine ratio, in association with morphologic improvement of tubulointerstitial lesions. The expression of laminin beta1 was not altered in any experimental groups. CONCLUSION: These results suggest that angiotensin II plays an important role in tubulointerstitial lesions in adriamycin-induced nephropathy.

Keyword

Adriamycin; Laminin beta1; Proteinuria; Renin-angiotensin system; Tubulointerstitial lesion

MeSH Terms

Angiotensin II
Animals
Blood Pressure
Cilazapril
Doxorubicin
Humans
Laminin
Losartan
Male
Proteinuria
Rats
Rats, Sprague-Dawley
Renin-Angiotensin System*
Angiotensin II
Cilazapril
Doxorubicin
Laminin
Losartan
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