- Cytoprotective and antioxidant effects of aged garlic extract against adriamycin-induced cardiotoxicity in adult male rats
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Nasr AY, Alshali RA
- KMID: 2503450
- Anat Cell Biol.
- 2020 Jun;53(2):201-215.
- doi: 10.5115/acb.19.236
Adriamycin (ADR) efficacy in cancer chemotherapy is well-established. However, ADR-induced cardiotoxicity remains a significant challenge. Aged garlic extract (AGE) is a natural polyphenol with high antioxidant potential. This study was... -
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- Renoprotective Effects of a Highly Selective A3 Adenosine Receptor Antagonist in a Mouse Model of Adriamycin-induced Nephropathy
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Min HS, Cha JJ, Kim K, Kim JE, Ghee JY, Kim H, Lee JE, Han JY, Jeong LS, Cha DR, Kang YS
- KMID: 2468272
- J Korean Med Sci.
- 2016 Sep;31(9):1403-1412.
- doi: 10.3346/jkms.2016.31.9.1403
The concentration of adenosine in the normal kidney increases markedly during renal hypoxia, ischemia, and inflammation. A recent study reported that an A3 adenosine receptor (A3AR) antagonist attenuated the progression... -
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- Histological Experimental Study on the Effect of Stem Cell Therapy on Adriamycin Induced Chemobrain
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Zickri1 MB, Abd El Aziz DH, Metwally H
- KMID: 2054550
- Int J Stem Cells.
- 2013 Nov;6(2):104-112.
BACKGROUND AND OBJECTIVES: Negative consequences of chemotherapy on brain function were suggested and were addressed in animal models as the clinical phenomenon of chemobrain .It was postulated that adriamycin (ADR)... -
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- Effect of Stem Cell Therapy on Adriamycin Induced Tubulointerstitial Injury
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Zickri MB, Zaghloul S, Farouk M, Abdel Fattah MM
- KMID: 1735407
- Int J Stem Cells.
- 2012 Nov;5(2):130-139.
BACKGROUND AND OBJECTIVES: It was postulated that adriamycin (ADR) induce renal tubulointerstitial injury. Clinicians are faced with a challenge in producing response in renal patients and slowing or halting the... -
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- Tissue Regeneration and Stem Cell Distribution in Adriamycin Induced Glomerulopathy
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Zickri MB, Abdel Fattah MM, Metwally H
- KMID: 1735405
- Int J Stem Cells.
- 2012 Nov;5(2):115-124.
BACKGROUND AND OBJECTIVES: Glomerulosclerosis develops secondary to various kidney diseases. It was postulated that adriamycin (ADR) induce chronic glomerulopathy. Treatment combinations for one year did not significantly modify renal function... -
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- The Comparative Study of Treatment Method on Adriamycin-Induced Extravasation Injury
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Moon IS, Lee CH, Kwon YS, Lee KC, Kim SK
- KMID: 1920340
- J Korean Soc Plast Reconstr Surg.
- 2009 May;36(3):269-276.
PURPOSE: Local skin necrosis after extravasation of adriamycin, a widely used chemotherapeutic agent, is a common problem in cancer patients. The extravasation of chemotherapeutic agents yields severe inflammatory responses, crust... -
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- The Expression of Cardiac Ankyrin Repeat Protein in an Animal Model of Adriamycin-Induced Cardiomyopathy
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Chung WB, Youn HJ, Choi YS, Park CS, Oh YS, Chung WS, Kim JH, Lee EH
- KMID: 1776345
- Korean Circ J.
- 2008 Sep;38(9):455-461.
- doi: 10.4070/kcj.2008.38.9.455
BACKGROUND AND OBJECTIVES: Cardiac ankyrin repeat protein (CARP) is an embryonic nuclear protein, and its expression is increased under conditions of pressure or volume overload and also in the failing... -
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- Effects of Cardiotrophin-1 on Adriamycin-Induced Apoptosis in H9c2 Cardiomyoblasts
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Shin JO, Ju ES, Song HM, Yun SH, Lim BK, Choi JH, Kim DK, Jeon ES
- KMID: 2225788
- Korean Circ J.
- 2008 May;38(5):264-269.
- doi: 10.4070/kcj.2008.38.5.264
BACKGROUND AND OBJECTIVES: Adriamycin (doxorubicin, ADR) is a highly effective anti-neoplastic drug, but its clinical use is limited by its adverse side effects on the heart. Cardiotrophin (CT-1), a potent... -
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- Gene Expression Changes of Drug-resistant Saos-2 Cells Induced by Anticancer Drug
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Bae MJ, Song IH, Kim SY
- KMID: 2128893
- Korean J Anat.
- 2007 Dec;40(4):297-310.
During the treatment of cancers, especially with anticancer drugs, the recurrence of cancer is the most important factor for survival rate. The most common cause of the recurrence is the... -
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- Effects of Adriamycin or CP-2 to the Rectal Mucosae of Mouse Implanted with Ehrlich Carcinoma Cells: An Autoradiographic Study
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Wang JW, Ko JS, Ahn ET, Park KH, Park DK
- KMID: 2224487
- Korean J Anat.
- 2005 Dec;38(6):505-514.
This experiment was performed to evaluate the morphological responses of the rectal intestinal glands of the mouse, inoculated with Ehrlich carcinoma cells, following administration of adriamycin or composition of the... -
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- Effects of Antitumor Agents to DNA Synthesis in the Gastric Epithelia of Mice Implanted with Ehrlich Carcinoma Cells: An Autoradiographic Study
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Ko JS, Choi PC, Ahn ET, Park KH, Park DK
- KMID: 2224486
- Korean J Anat.
- 2005 Dec;38(6):495-504.
This experiment was performed to evaluate the morphological responses of the gastric epithelium of the mouse, inoculated with Ehrlich carcinoma cells, following administration of 5-fluorouracil, adriamycin or mitomycin C. Healthy... -
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- The Preventive Effect of Dexrazoxane and Pentoxifylline on Adriamycin Induced Cardiomyopathy
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Ling Z, Bae EJ, Ha IS, Seo JW, Noh CI, Choi JY, Yun YS
- KMID: 1313594
- Korean J Pediatr.
- 2005 Dec;48(12):1378-1384.
PURPOSE: We hypothesized dexrazoxane (DXR) and pentoxifylline (PTX) may prevent myocardial damage in adriamycin (ADR) -induced cardiomyopathic rat model. We also investigated their effects on the myocardial apoptosis and fibrosis... -
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- Gene Expression of Metalloproteinases, Tissue Inhibitors of Metalloproteinases and Cytokines in Adriamycin-induced Cardiomyopathy
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Hong YM
- KMID: 2278660
- Korean J Pediatr.
- 2005 Feb;48(2):197-203.
PURPOSE: Changes in metalloproteinases(MMP) activity have been demonstrated in several disease states, including rheumatoid arthritis and tumor metastasis. More importantly, increased myocardial MMP activity has been reported to occur in... -
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- Effects of Renin-angiotensin System Blockade on Tubulointerstitial Lesions in Adriamycin-induced Nephropathy
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Lee DK, Han SW, Paik SS, Park MH, Lee JU, Kim HJ
- KMID: 2079422
- Korean J Nephrol.
- 2005 Jan;24(1):26-31.
PURPOSE: Effects of renin-angiotensin system blockade on tubulointerstitial lesions were examined in adriamycin-induced nephropathy. METHODS: Male Sprague-Dawley rats were used. The three experimental groups were intravenously injected with adriamycin (2... -
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- The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray
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Ahn MJ, Lee KH, Ahn JI, Yu DH, Lee HS, Choi JH, Jang JS, Bae JM, Lee YS
- KMID: 1807305
- Cancer Res Treat.
- 2004 Feb;36(1):43-49.
PURPOSE: Adriamycin(R) is one of the most commonly used drugs in the treatment of breast cancer. This study was performed to understand the molecular mechanisms of drug resistance in breast... -
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- Adriamycin Induced Apoptosis of H9c2 Cardiomyocytes via a Caspase-Independent Pathway
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Jeon MH, Youn HJ, Lee JH, Lee JH
- KMID: 1938857
- Korean Circ J.
- 2004 Jan;34(1):76-83.
- doi: 10.4070/kcj.2004.34.1.76
BACKGROUND: The cardiotoxicity of adriamycin limits its clinical usefulness as a powerful drug for solid tumors and malignant hematological disease. Although the exact mechanism by which it causes cardiac damage... -
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- Retrospective Study on the Therapeutic Effects of an Etoposide, Adriamycin, Cisplatin-II (EAP- II) versus an Etoposide, Leucovorin, 5-Furorouracil (ELF) Combination Chemotheraphy in Unresectable Gastric Cancer
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Moon HS, Kang YS, Kim YS, Park KO, Lee ES, Sung JK, Lee BS, Noh SM, Song KS, Cho JS, Shin KS, Jeong HY
- KMID: 1515760
- J Korean Gastric Cancer Assoc.
- 2003 Sep;3(3):122-127.
PURPOSE: The incidence rate and the mortality rate of gastric cancer have decreased in developed countries over the last several decades. On the other hand, they remain high in far... -
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- The Relation between Acute Adriamycin induced Cardiomyopathy and Apoptosis in rat : Study using 15 MHz High Frequency Transducer
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Choi YS, Park CS, Cho EJ, Jung HO, Jeon HK, Kang JH, Lee JH, Youn HJ, Chae JS, Kim JH, Cho KB, Hong SJ
- KMID: 2408609
- J Korean Soc Echocardiogr.
- 2002 Dec;10(2):35-43.
BACKGROUND: Anthracyclines, such as daunorubicin or doxorubicin that are one of the most widely used as chemotherapeutic agents in oncology clinics have the limitation of its usage because of severe... -
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- Changes in Laminin beta 1 Chain Expression in Renal Cortex by the Intervention with Cilazapril and Losartan on Adriamycin-Induced Nephropathy
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Kim TJ, Chung HS, Paik DJ, Youn JH, Kim WK
- KMID: 1559380
- Korean J Anat.
- 2002 Oct;35(5):419-429.
Laminin, an extracellular matrix glycoprotein, is distributed in the basement membrane of renal glomerulus. Laminin has been demonstrated to regulate the development and differentiation of glomeruli and play an important... -
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- Effects of Adriamycin or CP -2 on the Spleen of Mouse Implanted with Ehrlich Carcinoma Cells: An Autoradiographic Study
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Ko JS, Ahn ET, Park KH, Kim JG
- KMID: 2283132
- Korean J Phys Anthropol.
- 2002 Sep;15(3):185-195.
In this experiment, side effects of two anticancer drugs (adriamycin and CP -2) on the structure of spleen were histologically studied. Each of ICR mice was inoculated with 1 x10... -
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