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The Effects of Cilazapril on Left Ventricular Remodeling after Coronary Intervention in Patients with Ischemic Heart Failure

Park HW, Jeong MH, Lee SH, Kang KT, Kim JW, Kim SH, Cho JH, Ahn YK, Cho JG, Park JC, Kang YJ, Kang JC

BACKGROUND AND OBJECTIVES: Angiotensin converting enzyme inhibitor (ACEI) is known to be effective in the prevention of left ventricular failure (LVF) after acute myocardial infarction. The aim of this study...
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A clinical study on the anti-Hypertensive effect of cilazapril in patients with mild to moderate essential hypertension

Kim HH, Kim KS, Lim HK, Lee BH, Lee CK

BACKGROUND: In order to investigate the efficacy and safety of cilazapril, a recently developed angiotensin converting enzyme inhibitor, a clinical study was performed in the patients with mild to moderate...
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Effects of Renin-angiotensin System Blockade on Tubulointerstitial Lesions in Adriamycin-induced Nephropathy

Lee DK, Han SW, Paik SS, Park MH, Lee JU, Kim HJ

  • KMID: 2079422
  • Korean J Nephrol.
  • 2005 Jan;24(1):26-31.
PURPOSE: Effects of renin-angiotensin system blockade on tubulointerstitial lesions were examined in adriamycin-induced nephropathy. METHODS: Male Sprague-Dawley rats were used. The three experimental groups were intravenously injected with adriamycin (2...
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Upregulation of Renal Renin-Angiotensin System in Rats with Adriamycin-Induced Nephrosis

Kim SW, Lee JU, Han SW, Ryu JH, Oh YW, Kim NH, Choi KC, Kim HJ

  • KMID: 1615005
  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):127-130.
The present study was aimed to investigate whether the adriamycin-induced nephrosis is associated with an altered regulation of local renin-angiotensin system (RAS) in the kidney. Rats were subjected to a...
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A Clinical Study on the Anti-Hypertensive Effect of Cilazapril in Mild to Moderate Hypertensive Patients

Han DS, Choi JH, Choi WC, Ha SK, Lee HY, Lee WK

In order to investigate the efficacy and safety of oral cilazapril, a new angiotensin converting enzyme inhibitor, on essential hypertension, a single daily dose of 2.5 to 5.0mg cilazapril was...
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Changes in Laminin beta 1 Chain Expression in Renal Cortex by the Intervention with Cilazapril and Losartan on Adriamycin-Induced Nephropathy

Kim TJ, Chung HS, Paik DJ, Youn JH, Kim WK

  • KMID: 1559380
  • Korean J Anat.
  • 2002 Oct;35(5):419-429.
Laminin, an extracellular matrix glycoprotein, is distributed in the basement membrane of renal glomerulus. Laminin has been demonstrated to regulate the development and differentiation of glomeruli and play an important...
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The effects of antiproliferative drugs at stenotic area associated with primary atherosclerotic lesions in apoE knockout mouse - Change of vascular remodeling

Seo HS, Lee EM, Ahn JC, Kim SM, Hwang IH, Hwang KS, Song WH, Lim DS, Park CG, Kim YH, Shim WJ, Oh DJ, Ro YM

Apolipoprotein (apo) E deficient mouse can produce reproducible fixed stenotic primary atherosclerotic lesion, which reveals failure to remodel of vascular lumen, in the ascending aorta, external carotid, common carotid, iliac,...
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Randomized, Open Label, Multicenter Clinical Trial about the Effect of Cilazapril on Vascular Endothelial Function in Patients with Type 2 Diabetes Combined with Hypertension

Rhee SY, Woo JT, Baik SH, Lee HW, Lee IK, Kim HS, Lee MK, Shong MH, Cho CG, Park BH, Cha BS, Kim YS

  • KMID: 2331794
  • J Korean Diabetes Assoc.
  • 2006 Nov;30(6):450-458.
BACKGROUND: The angiotensin converting enzyme inhibitor (ACEi) improves the vascular endothelial cell function and has a better clinical outcome by decreasing the LDL cholesterol oxidation, hypercoagulability, oxidative stress and improving...
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