Korean J Nephrol.
1998 Sep;17(5):708-713.
The Change of Soluble Intercellular Adhesion Molecule-1 Levels in Hemorrhagic Fever with Renal Syndrome
Abstract
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The serum levels of sICAM-1 were significantly higher in febrile & hypotensive (789+/-241ng/ml) stage than in diuretic stage (514+/-151ng/ml) and convalescence stage (410+/-88ng/ml) (P<0.01). Also the serum levels of sICAM-1 in oliguric (628+/-220ng/ml) stage higher than that of convalescence stage (P<0.01). The serum level of sICAM-1 was significantly high in convalescence stage of patients with HFRS compared to control (306+/-75ng/ml) (P<0.01). sICAM-1 levels correlated with platelet count (R=-0.35, P<0.05) in all stage of HFRS. Our results suggest that the enhanced immune activation is a common feature in early stage of HFRS.