Korean J Obstet Gynecol.
2005 Dec;48(12):2903-2909.
Adenosine 5'-triphosphate induced NF-kappa B and intracellular calcium mobilization in cervical cancer cells
- Affiliations
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- 1Catholic Research Institutes of Medical Science, College of Medicine, The Catholic University of Korea.
- 2Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea. ahnws@catholic.ac.kr
- 3Department of Obstetrics and Gynecology, College of Medicine, Kyungbook National University, Taegu, Korea.
- 4Department of Obstetrics and Gynecology, College of Medicine, Chosun University, Gwangju, Korea.
- 5Department of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University, Bucheon, Korea.
- 6Koma Biotech, Seoul, Korea.
- 7College of Pharmacy, Seoul National University, Korea.
Abstract
OBJECTIVE
To know the effect of adenosine 5'-triphosphate (ATP) on intracellular calcium level and cell proliferation in cervical cancer cells.
METHODS
Study design: Four different human cervical cancer cell lines (Caski, C33A, HeLaS3 and SiHa) were used in this study. The change of intracellular calcium level, cell proliferation and the activity of proliferation- and calcium-related transcription factors by extracellular ATP were examined in these cell lines.
RESULTS
Extracellular ATP induced calcium mobilization, cell proliferation and the activation of NF-kappa B in all cell lines used.
CONCLUSION
These results suggest that calcium mobilization and NF-kappa B dependent signaling pathway play an important role in the cell proliferation by ATP in cervical cancer.
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