A Case of Ruptured Huge Granulosa Cell Tumor of the Ovary

Lee, K W; Ma, J N; Park, Y C; Lee, I S; Jung, K W; Kim, Y P

Abstract

Sex cord-stromal tumors of the ovary account for about 5-8% of all ovarian malignancies and most of sex cord-stromal tumors are granulosa cell tumors. The granulosa cell tumor has relatively low malignant potential, and secretes estrogen. The tumor occurs at any age, but mostly during reproductive and postmenopausal years. The bilaterality of the tumor is rare, and endometrial hyperplasia and endometrial cancer are often associated with this tumor. Sexual pseudoprecocity usually occurs in association with granulosa cell tumors. For perimenopausal and postmenopausal women, hysterectomy and bilateral salpingo-oophorectomy should be performed, however, unilateral salpingo-oophorectomy is appropriate therapy for stage Ia tumors in children or in women of reproductive age. The prognosis of the tumor is good except for the cases of recurrence or metastasis. Because of late recurrence, longterm follow-up should be recommended. Recently, a 53-year-old woman presented with several months' history of abdominal distension and low abdominal pain since one week ago. We have found 25X17X8 cm sized ovarian tumor on transabdominal ultrasonography in pelvic cavity. The tumor was ruptured and bilateral salpingo-oophorectomy was performed. We report here the clinicopathological study of a ruptured huge granulosa cell tumor with a brief review of literatures.