J Korean Neurol Assoc.  1999 Sep;17(5):761-763.

A Case of Marchiafava-Bignami Disease with Reversible Brain MRI Findings of Corpus Callosal Lesions

• Joung JH
• Sung KB
• Ahn MY
• Shin HK
• Park HK

Abstract

Marchiafava-Bignami disease(MBD), characterized by the primary degeneration of the corpus callosum, is a rare complication of chronic alcoholism. Recently, a few cases of MBD with reversible neuro-imaging abnormalities were reported. A 58-year-old, chronic alcoholic man was admitted with mental change, dysarthria, and a seizure attack. A T2-weighted Brain magnetic resonance imaging demonstrated high signal intensities in the body and splenium of the corpus callosum, multiple white matter, and cortical gray matter. Treatment with a multiple vitamin complex resulted in a near complete recovery of neurological manifestation. A brain MRI obtained four weeks after admission revealed a dramatic resolution of previous imaging abnormalities. We report a case of Marchiafava-Bignami disease with reversible neuro-imaging abnormalities.

Keyword

Chronic alcoholism; Marchiafava-Bignami disease; MRI

MeSH Terms

Alcoholics
Alcoholism
Brain*
Corpus Callosum
Dysarthria
Humans
Magnetic Resonance Imaging*
Marchiafava-Bignami Disease*
Middle Aged
Neurologic Manifestations
Seizures
Vitamins
Vitamins