J Korean Neurol Assoc.  1999 Sep;17(5):764-766.

Two Cases of Marchiafava-Bignami Disease

Affiliations
  • 1Department of Neurology, Chonbuk National University Medical School.
  • 2Institute for Medical Sciences.

Abstract

We described 2 patients with Marchiafava-Bignami disease, a neurological disorder associated with chronic alcohol consumption. Patient 1 expressed general weakness and confusion, while patient 2 expressed dysphagia and seizures. Lesions involving the corpus callosum were identified with T2 weighted MR imaging in which there was a hyperintensity in the splenium of patient 1 and in the entire corpus callosum of patient 2. While the conditions of both patients were improved by with nutritional support, they were left with cognitive impairment.

Keyword

Marchiafava-Bignami disease; Corpus callosum; Demyelination

MeSH Terms

Alcohol Drinking
Corpus Callosum
Deglutition Disorders
Demyelinating Diseases
Humans
Magnetic Resonance Imaging
Marchiafava-Bignami Disease*
Nervous System Diseases
Nutritional Support
Seizures
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