J Korean Neurol Assoc.  2008 Nov;26(4):376-378.

Acute Marchiafava-Bignami Disease With Typical White Matter Involvement on Diffusion Weighted MRI

• Shin HE
• Kim JG
• Jo SR
• Jeong SH
• Yoon SJ

Abstract

Marchiafava-Bignami disease (MBD) is characterized by cerebral white matter lesions associated with chronic alcoholism. Premortem diagnosis of MBD is usually based on history and clinical manifestations. We report a case of acute MBD in which diffusion-weighted MRI (DWI) showed high signal intensities along the white matter including the corpus callosum. DWI may be useful in premortem diagnosis of acute MBD.

Keyword

Marchiafava-Bignami disease; White matter disease; DWI

MeSH Terms

Alcoholism
Corpus Callosum
Diffusion
Diffusion Magnetic Resonance Imaging
Humans
Leukoencephalopathies
Marchiafava-Bignami Disease