Korean J Thorac Cardiovasc Surg.
2010 Oct;43(5):482-489.
The Clinical Value of Intima-media Thickness in Patients with Stable Coronary Artery Disease and C-reactive Protein within Normal Limits
- Affiliations
-
- 1Department of Thoracic and Cardiovascular Surgery, Daejeon St. Mary's Hospital, The Catholic University of Korea, School of Medicine, Korea. phenix@catholic.ac.kr
- 2Department of Thoracic and Cardiovascular Surgery, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, School of Medicine, Korea.
- 3Department of Thoracic and Cardiovascular Surgery, St. Paul's Hospital, The Catholic University of Korea, School of Medicine, Korea.
- 4Division of Cardiology, Department of Internal Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea, School of Medicine, Korea.
Abstract
- BACKGROUND
The purpose of this study was to determine whether hand-measured carotid intima-media thickness (IMT) was a reliable and simple tool that could be used to evaluate the severity of stable coronary artery disease (CAD) with normal high-sensitivity C-reactive protein (CRP). MATERIAL AND METHOD: We examined left carotid IMTs in 688 patients with stable CAD and excluded 121 patients with abnormally elevated hs-CRP (> or =0.5 mg/dL). We sought to determine the association between risk factors and the severity of stable CAD and carotid IMT in 567 patients who were divided into lower and higher groups based on the median value. Patients underwent a coronary artery angiogram and had at least significant stenosis (>50% of the original luminal diameter involving one or more major coronary artery). RESULT: Of the 567 patients, 300 (52.9%) were in the lower IMT group and 267 (47.1%) were in the higher IMT group; the median value was 0.76 mm. By multivariable logistic regression analysis, the following groups were different: older age (~49 vs. 70~ years, respectively; OR=6.552), high FBS (~99 vs. 120~ mg/dL; OR=1.713) and severity of CAD (1 vessel vs. 2 vessel disease; OR=1.711, 1 vessel vs. 3 vessel disease; OR=1.714).
CONCLUSION
We conclude that there are correlations between increased carotid IMT and severity of CAD in stable angina patients with normal CRP levels.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Carotid ultrasound in patients with coronary artery disease
- Association of Carotid Artery Parameters of Atherosclerosis in Coronary Artery Disease
- Measurements of Carotid Intima, Media, and Intima-media Thickness and Their Clinical Importance
- Extra-Cardiac Imaging: How to Assess Early Atherosclerosis using High-Resolution Ultrasound
- The Limitation in Measurement of Carotid Intima Media Thickness in Type 2 Diabetics with or without Coronary Artery Disease
