J Korean Cancer Assoc.  1999 Oct;31(5):972-978.

A Phase 2 Study with Vinorelbine and Ifosfamide in the Inoperable Non - small Cell Lung Cancer

• Lee MH
• Yoo YJ
• Bang SM
• Joung GH
• Kim HJ
• Shin DB
• Lee SN
• Kim SR
• Heo DS
• Bang YJ
• Kim NK

Abstract

PURPOSE: A phase II study of vinorelbine and ifosfamide combination chemotherapy in patients with advanced or recurrent non-small cell lung cancer (NSCLC) was conducted to assess response rate, response duration, and toxicites.
MATERIALS AND METHODS
Patients with advanced NSCLC who had no prior systemic chemotherapy were eligible. They have no central nervous system metastasis and recurrent or progressive disease after surgery or radiotherapy. Each cycle consisted of vinorelbine 25 mg/m' i.v. days 1 & 8, and ifosfamide 2 g/m i.v. days 1, 2 & 3 with Mesna and treatments were repeated every 21 days.
RESULTS
Forty patients with advanced or recurrent NSCLC were treated at multi center between March, 1997 and March, 1998. Six patients were not evaluable because five patients refused therapy after the first course and one patient was protocol violation. Of 34 evaluable patients, objective responses were seen in 11 (32.4%) patients (CR 0%, PR 32.4%). The median duration of response was 16.4 weeks. The median overall survival was 9.5 months. The toicities of this regimen were acceptable without treatment related toxic death.
CONCLUSION
We concluded that combination regimen of vinorelbine and ifosfamide was effective and tolerable in the treatment of advanced non-small cell lung cancer.

Keyword

Vinorelbine; Ifosfamide; Non-small cell lung cancer

MeSH Terms

Carcinoma, Non-Small-Cell Lung
Central Nervous System
Drug Therapy
Drug Therapy, Combination
Humans
Ifosfamide*
Mesna
Neoplasm Metastasis
Radiotherapy
Small Cell Lung Carcinoma*
Ifosfamide
Mesna