J Biomed Res.
2013 Mar;14(1):8-12.
Comparison of blood concentration for oral administration of micronized and non-micronized amoxicillin in Sprague-Dawley rats
- Affiliations
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- 1Food and Drug Analysis Section, Chungcheongbuk-do Institute of Health and Environment, Cheongwon 363-951, Korea.
- 2Engineering Research Institute, Department of Industrial Systems Engineering, Gyeongsang National University, Chinju 600-701, Korea.
- 3Tongyeong National Quarantine Station, Ministry of Health & Welfare, Tongyeong 650-110, Korea.
- 4Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University, Busan 602-703, Korea.
- 5College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Korea.
- 6Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Chinju 600-701, Korea. hujang@gnu.ac.kr
Abstract
- Amoxicillin, a well-known antibiotic, has a broad spectrum against gram-negative and gram-positive bacteria. This experiment was conducted in order to investigate the effect of micronized and non-micronized amoxicillin prepared using different comminution techniques on change in blood concentration of rats. Forty adult male Sprague Dawley rats (6~7 weeks of age, body weight 128.3 +/- 10.7 g) were randomly allocated to two treatment groups: micronized amoxicillin (MA) group treated with micronized amoxicillin trihydrate powder (particle size, over 90% of 10 microm), non-micronized amoxicillin (NMA) group treated with non-micronized amoxicillin trihydrate powder (particle size, over 70% of 100 microm), given 480 mg/kg body weight once daily for four days. The results showed a significant increase in serum concentration in the MA group on days 3 and 4, compared to the NMA group (P<0.05). In particular, serum concentration of the MA group on day 4 was increased almost two times that of the NMA group. The results indicate that due to the increase of the drug's oral bioavailability, higher serum concentration would be achieved with the micronized amoxicillin trihydrate than with the non-micronized drug.
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