Toxicol Res.
2012 Mar;28(1):25-31.
Acute Pulmonary Toxicity and Body Distribution of Inhaled Metallic Silver Nanoparticles
- Affiliations
-
- 1Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea. mchotox@snu.ac.kr
- 2Department of Nanofusion Technology, Graduate School of Convergence Science and Technology, Seoul National University, Suwon 443-270, Korea.
- 3Center for Materials Measurement, Division of Industrial Metrology, Korea Research Institute of Standards and Science, Daejeon 305-340, Korea.
- 4HCT, Icheon 467-701, Korea.
- 5Wonjin Institute of Occupational and Environmental Health, Seoul 131-831, Korea.
- 6R&D Center, Biterials Co., Ltd., Seoul 140-200, Korea. lifeisgood@biterials.com
- 7Advanced Institute of Convergence Technology, Seoul National University, Suwon 443-270, Korea.
Abstract
- The purpose of this study was to determine the acute pulmonary toxicity of metallic silver nanoparticles (MSNPs, 20.30 nm in diameter). Acute pulmonary toxicity and body distribution of inhaled MSNPs in mice were evaluated using a nose-only exposure chamber (NOEC) system. Bronchoalveolar lavage (BAL) fluid analysis, Western blotting, histopathological changes, and silver burdens in various organs were determined in mice. Mice were exposed to MSNPs for 6 hrs. The mean concentration, total surface area, volume and mass concentrations in the NOEC were maintained at 1.93 x 10(7) particles/cm3, 1.09 x 10(10) nm2/cm3, 2.72 x 10(11) nm3/cm3, and 2854.62 microg/m3, respectively. Inhalation of MSPNs caused mild pulmonary toxicity with distribution of silver in various organs but the silver burdens decreased rapidly at 24-hrs post-exposure in the lung. Furthermore, inhaled MSNPs induced activation of mitogen-activated protein kinase (MAPK) signaling in the lung. In summary, single inhaled MSNPs caused mild pulmonary toxicity, which was associated with activated MAPK signaling. Taken together, our results suggest that the inhalation toxicity of MSNPs should be carefully considered at the molecular level.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Silver Nanoparticles as a Smart Antimicrobial Agent
- Size-dependent toxicity of silver nanoparticles to Glyptotendipes tokunagai
- In vivo Genotoxicity of Silver Nanoparticles after 90-day Silver Nanoparticle Inhalation Exposure
- Phagocytosis and Endocytosis of Silver Nanoparticles Induce Interleukin-8 Production in Human Macrophages
- Inhibition Effects of Silver Nanoparticles against Powdery Mildews on Cucumber and Pumpkin
