Electrolyte Blood Press.  2015 Jun;13(1):1-6. 10.5049/EBP.2015.13.1.1.

A Minireview on Vasopressin-regulated Aquaporin-2 in Kidney Collecting Duct Cells

Affiliations
  • 1Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea. thkwon@knu.ac.kr

Abstract

The kidney collecting duct is an important renal tubular segment for the regulation of body water and salt homeostasis. Water reabsorption in the collecting duct cells is regulated by arginine vasopressin (AVP) via the vasopressin V2-receptor (V2R). AVP increases the osmotic water permeability of the collecting duct cells through aquaporin-2 (AQP2) and aquaporin-3 (AQP3). AVP induces the apical targeting of AQP2 and transcription of AQP2 gene in the kidney collecting duct principal cells. The signaling transduction pathways resulting in the AQP2 trafficking to the apical plasma membrane of the collecting duct principal cells, include AQP2 phosphorylation, RhoA phosphorylation, actin depolymerization and calcium mobilization, and the changes of AQP2 protein abundance in water balance disorders have been extensively studied. These studies elucidate the underlying cellular and molecular mechanisms of body water homeostasis and provide the basis for the treatment of body water balance disorders.

Keyword

Arginine vasopressin; Aquaporins; Body water balance

MeSH Terms

Actins
Aquaporin 2*
Aquaporins
Arginine Vasopressin
Body Water
Calcium
Cell Membrane
Homeostasis
Kidney Tubules, Collecting*
Permeability
Phosphorylation
Vasopressins
Water-Electrolyte Balance Body Water
Actins
Aquaporin 2
Aquaporins
Arginine Vasopressin
Calcium
Vasopressins
Water-Electrolyte Balance Body Water

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