Pediatr Gastroenterol Hepatol Nutr.  2013 Sep;16(3):153-161. 10.5223/pghn.2013.16.3.153.

Polyunsaturated Fatty Acids in Children

Affiliations
  • 1Department of Pediatrics, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Korea. e-z-up@daum.net

Abstract

Polyunsaturated fatty acids (PUFAs) are the major components of brain and retina, and are the essential fatty acids with important physiologically active functions. Thus, PUFAs should be provided to children, and are very important in the brain growth and development for fetuses, newborn infants, and children. Omega-3 fatty acids decrease coronary artery disease and improve blood flow. PUFAs have been known to have anti-inflammatory action and improved the chronic inflammation such as auto-immune diseases or degenerative neurologic diseases. PUFAs are used for metabolic syndrome related with obesity or diabetes. However, there are several considerations related with intake of PUFAs. Obsession with the intake of unsaturated fatty acids could bring about the shortage of essential fatty acids that are crucial for our body, weaken the immune system, and increase the risk of heart disease, arrhythmia, and stroke. In this review, we discuss types, physiologic mechanism of action of PUFAs, intake of PUFAs for children, recommended intake of PUFAs, and considerations for the intake of PUFAs.

Keyword

Fatty acid; Unsaturaed; Omega-3; Omega-6; Child

MeSH Terms

Arrhythmias, Cardiac
Brain
Child
Coronary Artery Disease
Fatty Acids, Essential
Fatty Acids, Omega-3
Fatty Acids, Unsaturated
Fetus
Growth and Development
Heart Diseases
Humans
Immune System
Infant, Newborn
Inflammation
Neurodegenerative Diseases
Obesity
Obsessive Behavior
Retina
Stroke
Fatty Acids, Essential
Fatty Acids, Omega-3
Fatty Acids, Unsaturated

Reference

1. Bang HO, Dyerberg J, Sinclair HM. The composition of the Eskimo food in north western Greenland. Am J Clin Nutr. 1980; 33:2657–2661. PMID: 7435433.
Article
2. Kagawa Y, Nishizawa M, Suzuki M, Miyatake T, Hamamoto T, Goto K, et al. Eicosapolyenoic acids of serum lipids of Japanese islanders with low incidence of cardiovascular diseases. J Nutr Sci Vitaminol (Tokyo). 1982; 28:441–453. PMID: 7175583.
Article
3. Siscovick DS, Raghunathan TE, King I, Weinmann S, Wicklund KG, Albright J, et al. Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. JAMA. 1995; 274:1363–1367. PMID: 7563561.
Article
4. Albert CM, Campos H, Stampfer MJ, Ridker PM, Manson JE, Willett WC, et al. Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med. 2002; 346:1113–1118. PMID: 11948270.
Article
5. Lemaitre RN, King IB, Mozaffarian D, Kuller LH, Tracy RP, Siscovick DS. n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study. Am J Clin Nutr. 2003; 77:319–325. PMID: 12540389.
Article
6. Burr ML, Fehily AM, Gilbert JF, Rogers S, Holliday RM, Sweetnam PM, et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet. 1989; 2:757–761. PMID: 2571009.
Article
7. GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet. 1999; 354:447–455. PMID: 10465168.
8. Harris WS, Connor WE, McMurry MP. The comparative reductions of the plasma lipids and lipoproteins by dietary polyunsaturated fats: salmon oil versus vegetable oils. Metabolism. 1983; 32:179–184. PMID: 6827988.
Article
9. Harris WS, Rambjør GS, Windsor SL, Diederich D. n-3 fatty acids and urinary excretion of nitric oxide metabolites in humans. Am J Clin Nutr. 1997; 65:459–464. PMID: 9022531.
Article
10. Pan A, Chen M, Chowdhury R, Wu JH, Sun Q, Campos H, et al. α-linoleic acid and risk of cardiovascular disease: a systematic review and meta-analysis. Am J Clin Nutr. 2012; 96:1262–1273. PMID: 23076616.
11. Krishnamurti C, Stewart MW, Cutting MA, Rothwell SW. Assessment of omega-fatty-acid-supplemented human platelets for potential improvement in long-term storage. Thromb Res. 2002; 105:139–145. PMID: 11958804.
12. Goodnight SH Jr, Harris WS, Connor WE. The effects of dietary omega 3 fatty acids on platelet composition and function in man: a prospective, controlled study. Blood. 1981; 58:880–885. PMID: 7295999.
Article
13. McVeigh GE, Brennan GM, Cohn JN, Finkelstein SM, Hayes RJ, Johnston GD. Fish oil improves arterial compliance in non-insulin-dependent diabetes mellitus. Arterioscler Thromb. 1994; 14:1425–1429. PMID: 8068603.
Article
14. Federation of American Societies for Experimental Biology. Anti-inflammatory effects of omega 3 fatty acid in fish oil linked to lowering of prostaglandin [Internet]. Rockville (MD): Science Daily;2006. cited 2013 Sep 13. Available from http://www.sciencedaily.com/releases/2006/04/060404085719.htm.
15. Serhan CN. Novel omega -- 3-derived local mediators in anti-inflammation and resolution. Pharmacol Ther. 2005; 105:7–21. PMID: 15626453.
16. Singer P, Shapiro H, Theilla M, Anbar R, Singer J, Cohen J. Anti-inflammatory properties of omega-3 fatty acids in critical illness: novel mechanisms and an integrative perspective. Intensive Care Med. 2008; 34:1580–1592. PMID: 18461305.
Article
17. Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-ensitizing effects. Cell. 2010; 142:687–698. PMID: 20813258.
18. Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr. 2002; 21:495–505. PMID: 12480795.
Article
19. Kalupahana NS, Claycombe KJ, Moustaid-Moussa N. (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. Adv Nutr. 2011; 2:304–316. PMID: 22332072.
Article
20. Kopecky J, Rossmeisl M, Flachs P, Kuda O, Brauner P, Jilkova Z, et al. n-3 PUFA: bioavailability and modulation of adipose tissue function. Proc Nutr Soc. 2009; 68:361–369. PMID: 19698199.
Article
21. Kalupahana NS, Claycombe K, Newman SJ, Stewart T, Siriwardhana N, Matthan N, et al. Eicosapentaenoic acid prevents and reverses insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation. J Nutr. 2010; 140:1915–1922. PMID: 20861209.
Article
22. Madsen L, Petersen RK, Kristiansen K. Regulation of adipocyte differentiation and function by polyunsaturated fatty acids. Biochim Biophys Acta. 2005; 1740:266–286. PMID: 15949694.
Article
23. Birch EE, Garfield S, Hoffman DR, Uauy R, Birch DG. A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med Child Neurol. 2000; 42:174–181. PMID: 10755457.
Article
24. Decsi T. Effects of supplementing LCPUFA to the diet of pregnant women: data from RCT. Adv Exp Med Biol. 2009; 646:65–69. PMID: 19536664.
Article
25. Olsen SF, Østerdal ML, Salvig JD, Mortensen LM, Rytter D, Secher NJ, et al. Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial. Am J Clin Nutr. 2008; 88:167–175. PMID: 18614738.
Article
26. Gould JF, Smithers LG, Makrides M. The effect of maternal omega-3 (n-3) LCPUFA supplementation during pregnancy on early childhood cognitive and visual development: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 2013; 97:531–544. PMID: 23364006.
Article
27. Morale SE, Hoffman DR, Castañeda YS, Wheaton DH, Burns RA, Birch EE. Duration of long-chain polyunsaturated fatty acids availability in the diet and visual acuity. Early Hum Dev. 2005; 81:197–203. PMID: 15748975.
Article
28. Hoffman DR, Theuer RC, Castañeda YS, Wheaton DH, Bosworth RG, O'Connor AR, et al. Maturation of visual acuity is accelerated in breast-fed term infants fed baby food containing DHA-enriched egg yolk. J Nutr. 2004; 134:2307–2313. PMID: 15333721.
Article
29. Gillies D, Sinn JKH, Lad SS, Leach MJ, Ross MJ. Polyunsaturated fatty acids (PUFA) for attention deficit hyperactivity disorder (ADHD) in children and adolescents. Cochrane Database Syst Rev. 2012; 7:CD007986. PMID: 22786509.
Article
30. Tan ML, Ho JJ, Teh KH. Polyunsaturated fatty acids (PUFAs) for children with specific learning disorders. Cochrane Database Syst Rev. 2012; 12:CD009398. PMID: 23235675.
Article
31. Li J, Xun P, Zamora D, Sood A, Liu K, Daviglus M, et al. Intakes of long-chain omega-3 (n-3) PUFAs and fish in relation to incidence of asthma among American young adults: the CARDIA study. Am J Clin Nutr. 2013; 97:173–178. PMID: 23193002.
Article
32. Engler MM, Engler MB, Malloy M, Chiu E, Besio D, Paul S, et al. Docosahexaenoic acid restores endothelial function in children with hyperlipidemia: results from the EARLY study. Int J Clin Pharmacol Ther. 2004; 42:672–679. PMID: 15624283.
Article
33. Trumbo P, Schlicker S, Yates AA, Poos M. Food and Nutrition Board of the Institute of Medicine, The National Academies. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids. J Am Diet Assoc. 2002; 102:1621–1630. PMID: 12449285.
Article
34. Leaf A, Jorgensen MB, Jacobs AK, Cote G, Schoenfeld DA, Scheer J, et al. Do fish oils prevent restenosis after coronary angioplasty? Circulation. 1994; 90:2248–2257. PMID: 7955181.
Article
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