Tuberc Respir Dis.  1998 Aug;45(4):888-895. 10.4046/trd.1998.45.4.888.

Two Cases of Falciparum Malaria with Acute Respiratory Distress Syndrome

Affiliations
  • 1Department of Internal medicine, Asan Medical Center, University of Ulsan, Collge of Medicine, Seoul, Korea.
  • 2Department of Diagnostic pathology, Asan Medical Center, University of Ulsan, Collge of Medicine, Seoul, Korea.
  • 3Department of Clinical pathology, Asan Medical Center, University of Ulsan, Collge of Medicine, Seoul, Korea.

Abstract

Malaria is one of the most common infectious diseases in the world. Plasmodium falciparum accounting for nearly all malaria mortality, kills an estimated 1 to 2 million persons yearly and has several features thai make it deadlist of malarias. While cerebral malaria is the most common presentation of severe disease, acute lung injury associated with malaria is uncommon but serious and fatal complication. We report two cases of severe malaria with ARDS and multi-organ failure. All two patients traveled to foreign countries, Kenya, Papua New Guinea where choroquine-resistant malaria is distributed. The first case, which developed cerebral malaria hypoglycemia, multi-organ failure, and ARDS, treated with quinine and mechanical ventilator, but expired due to oxygenation failure. Autopsy showed acute necrotizing infiltration, diffuse eosinophilic fibrinoid deposits along the alveolar space, and alveolar macrophage with malaria pigment The second case also developed multi-organ failure, followed by ARDS, and was treated with quinine, exchange transfusion, plasmapheresis, and mechanical ventilator. He recovered with residual restrictive lung change after treatment.

Keyword

Falciparum malaria; Lung injury; ARDS; Multi-organ failure

MeSH Terms

Acute Disease
Asian Continental Ancestry Group
Autopsy
Communicable Diseases
Eosinophils
Humans
Hypoglycemia
Kenya
Lung
Lung Injury
Macrophages, Alveolar
Malaria*
Malaria, Cerebral
Mortality
Oxygen
Papua New Guinea
Plasmapheresis
Plasmodium falciparum
Quinine
Respiratory Distress Syndrome, Adult*
Ventilators, Mechanical
Oxygen
Quinine

Cited by  1 articles

Evaluation of the LG Advansure™ Malaria P.f./P.v. real-time QPCR for the Diagnosis of Malaria
Hye Jin Lee, Ha Nui Kim, Byong Joon Yoo, Jang Su Kim, Myong Han Kim, Chae Seung Lim, Kap No Lee
Lab Med Online. 2011;1(2):100-104.    doi: 10.3343/lmo.2011.1.2.6.

Full Text Links
  • TRD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr