Pediatr Infect Vaccine.  2017 Aug;24(2):117-122. 10.14776/piv.2017.24.2.117.

Blackwater Fever Followed by Severe Falciparum Malaria in a Child

Affiliations
  • 1Department of Pediatrics, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, the Republic of Korea. eunchoi@snu.ac.kr

Abstract

Blackwater fever is a serious clinical syndrome manifested by acute intravascular hemolysis, fever, and the passage of black or red urine, which is classically associated with falciparum malaria and irregular administration of quinine. In Korea, Plasmodium vivax is the only endemic malaria circulating; a number of imported cases of falciparum malaria have been reported in patients following return from international travel to a malaria endemic area. Therefore, it is important for health care professionals including pediatricians to be aware of the falciparum malaria and its clinical courses. Herein, we report a case of a 14-year-old girl with severe falciparum malaria that was complicated by blackwater fever.

Keyword

Blackwater fever; Quinine; Malaria, falciparum; Korea

MeSH Terms

Adolescent
Blackwater Fever*
Child*
Delivery of Health Care
Female
Fever
Hemolysis
Humans
Korea
Malaria*
Malaria, Falciparum
Plasmodium vivax
Quinine
Quinine

Figure

  • Fig. 1 Different morphological characteristics of Plasmodium falciparum observed in the case patient: (A) marginal form; (B) binucleate form; (C) polyparasitism (thin film; Wright-Giemsa stain, ×1,000).


Reference

1. John CC. Malaria (Plasmodium). Kliegman RM, Stanton BM, St Geme J, Schor NF, editors. Nelson textbook of pediatrics. 20th ed. Philadelphia: Elsevier;2015. p. 1709–1721.
2. Boctor FN. Red blood cell exchange transfusion as an adjunct treatment for severe pediatric falciparum malaria, using automated or manual procedures. Pediatrics. 2005; 116:e592–e595.
Article
3. World Health Organization. Severe malaria. Trop Med Int Health. 2014; 19:Suppl 1. 7–131.
4. Tran TH, Day NP, Ly VC, Nguyen TH, Pham PL, Nguyen HP, et al. Blackwater fever in southern Vietnam: a prospective descriptive study of 50 cases. Clin Infect Dis. 1996; 23:1274–1281.
Article
5. Park JW, Klein TA, Lee HC, Pacha LA, Ryu SH, Yeom JS, et al. Vivax malaria: a continuing health threat to the Republic of Korea. Am J Trop Med Hyg. 2003; 69:159–167.
Article
6. Korea Centers for Disease Control and Prevention. Epidemiologic characteristics of imported malaria in Korea, 2003-2012 [Internet]. Cheongju: KCDC;c2012. cited 2017 May 30. Available from: http://cdc.go.kr/CDC/info/CdcKrInfo0301.jsp?menuIds=HOME001-MNU1154-MNU0005-MNU0037-MNU1380&cid=22134.
7. American Academy of Pediatrics. Malaria. Kimberlin DW, Long SS, Brady MT, Jackson MA, editors. Red book: 2015 report of the Committee on Infectious Diseases. 30th ed. Elk Grove Village: American Academy of Pediatrics;2015. p. 528–535.
8. Lee SY, Ko TS, Chi HS, Park YS. Four cases of the imported falciparum malaria in children. J Korean Pediatr Soc. 1997; 40:249–254.
9. Griffith KS, Lewis LS, Mali S, Parise ME. Treatment of malaria in the United States: a systematic review. JAMA. 2007; 297:2264–2277.
10. Obonyo CO, Juma EA. Clindamycin plus quinine for treating uncomplicated falciparum malaria: a systematic review and meta-analysis. Malar J. 2012; 11:2.
Article
11. Chung HS, Peck KR, Kim DW. Two case reports of successful therapeutic erythrocytapheresis as an adjunctive therapy in severe falciparum malaria. Ther Apher Dial. 2010; 14:230–233.
Article
12. World Health Organization, Division of. Severe and complicated malaria. Trans R Soc Trop Med Hyg. 1990; 84:Suppl 2. 1–65.
Article
13. Bruce-Chwatt LJ. Quinine and the mystery of blackwater fever. Acta Leiden. 1987; 55:181–196.
14. Delacollette C, Taelman H, Wery M. An etiologic study of hemoglobinuria and blackwater fever in the Kivu Mountains, Zaire. Ann Soc Belg Med Trop. 1995; 75:51–63.
15. Bruneel F, Gachot B, Wolff M, Regnier B, Danis M, Vachon F, et al. Resurgence of blackwater fever in long-term European expatriates in Africa: report of 21 cases and review. Clin Infect Dis. 2001; 32:1133–1140.
Article
16. de Villiers KA, Marques HM, Egan TJ. The crystal structure of halofantrine-ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials. J Inorg Biochem. 2008; 102:1660–1667.
Article
17. World Health Organization. World malaria report 2015 [Internet]. Geneva: World Health Organization;c2017. cited 2017 May 30. Available from: http://www.who.int/malaria/publications/world-malaria-report-2015/report/en/.
18. Korea Centers for Disease Control and Prevention. Guidelines for malaria prevention and control 2016 [Internet]. Cheongju: KCDC;c2012. cited 2017 May 30. Available from: http://cdc.go.kr.
Full Text Links
  • PIV
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr