Korean J Anesthesiol.  2002 Feb;42(2):161-166. 10.4097/kjae.2002.42.2.161.

Sedative Effect and Cardiovascular Stability of Lidocaine during Endotracheal Intubation under Bispectral Index (BIS) Monitoring

• Shim KD
• Lee JS
• Shim YH
• Jung JH
• Nam SB

• KMID: 2039800
• DOI: http://doi.org/10.4097/kjae.2002.42.2.161

Abstract

BACKGROUND: Lidocaine's sedative effect has not been known well. The purpose of this study was to evaluate its sedative and cardiovascular effects during induction of anesthesia.
METHODS
Twenty patients were randomly allocated to group I or II, with or without lidocaine 1.5 mg/kg intravenously (IV) before induction, respectively. The BIS, blood pressure and heart rate were measured at before and 2 minutes after lidocaine IV injection, preintubation, and 1, 2, 3 and 5 minutes after tracheal intubation. The enflurane concentrations were continuously maintained at 2 volume%.
RESULTS
The BIS of group I was more decreased at 1 and 2 minutes after intubation than those of group II. The systolic blood pressures of group I were less increased at 1 and 2 minutes after intubation than those of group II. The diastolic blood pressures and heart rates of group I were not different from those of group II at each stage of the procedure.
CONCLUSIONS
Lidocaine reduced BIS and blunted the intubation-induced systolic hypertensive response. In addition it is thought that it has a sedative effect and is effective to maintain cardiovascular stability after tracheal intubation.

Keyword

Bispectral index; cardiovascular stability; endotracheal intubation; lidocaine; sedative effect

MeSH Terms

Anesthesia
Blood Pressure
Enflurane
Heart Rate
Humans
Hypnotics and Sedatives*
Intubation
Intubation, Intratracheal*
Lidocaine*
Enflurane
Hypnotics and Sedatives
Lidocaine