Anesth Pain Med.  2008 Apr;3(2):103-107.

The Change of Bispectral Index in Endotracheal Intubation with Propofol and Remifentanil without Muscle Relaxant

• Cho HS
• Oh SC
• Chung KD
• Son YS
• Ryu KH
• Oh H
• Lee SM

Abstract

BACKGROUND: There have been conflicting reports about the effect of muscle relaxant to bispectral index during propofol anesthesia. The purpose of this study was to investigate the change of bispectral index (BIS) in endotracheal intubation with propofol and remifentanil without muscle relaxant and to compare with those in endotracheal intubation with muscle relaxant.
METHODS
Forty-eight ASA physical status I or II patients were randomly allocated to 2 groups. Each patient were anesthetized with propofol at target effect site concentration of 4.0microg/ml with remifentanil 3.0microg/kg. Saline was injected in Group S and rocuronium 0.6 mg/kg was injected in Group R. Intubation was attempted, and the BIS, intubating condition, mean arterial pressure and heart rate were observed up to 5 minutes after intubation.
RESULTS
BIS was elevated after intubation in Group S. BIS after intubation in group S were significantly higher than group R. BIS after injection of rocuronium in group R was significantly decreased. There were no significant differences in hemodynamic datas in two groups. Intubation condition was acceptable in all patients.
CONCLUSIONS
The BIS in endotracheal intubation with propofol and remifentanil without muscle relaxantI can be higher than in endotracheal intubation with muscle relaxant.

Keyword

bispectral index; endotracheal intubation; muscle relaxant; propofol; remifentanil

MeSH Terms

Androstanols
Anesthesia
Arterial Pressure
Heart Rate
Hemodynamics
Humans
Intubation
Intubation, Intratracheal
Muscles
Piperidines
Propofol
Androstanols
Piperidines
Propofol