Korean J Anesthesiol.  2007 Dec;53(6):695-699. 10.4097/kjae.2007.53.6.695.

The Influence of Remifentanil on the Bispectral Index during Intubation under TIVA using Propofol

• Lee JH
• Kim SI
• Kim MG
• Kim SC
• Ok SY

• KMID: 1937334
• DOI: http://doi.org/10.4097/kjae.2007.53.6.695

Abstract

BACKGOUND: The present study was undertaken to determine the effect of remifentanil on the bispectral index (BIS) during intubation under TIVA (total intravenous anesthesia) using propofol.
METHODS
In this prospective, randomized, double-blind study, 80 healthy patients aged 18~60 years undergoing elective surgery were investigated. Anesthesia was induced using propofol (target effect-site concentration 4microgram/ml). After the loss of consciousness, rocuronium (0.9 mg/kg) and remifentanil was infused. The patients in the R group were infused with remifentanil using a target effect-site concentration of 4 ng/ml, and patients in the P group were infused with saline. The BIS value, mean arterial pressure (MAP) and heart rate (HR) were measured before induction, before remifentanil infusion and before and after tracheal intubation.
RESULTS
The BIS value remained constant after intubation in the two groups. The MAP and HR increased significantly after intubation in the two groups, but the degree of increase of MAP and HR was less in group R than in group P significantly.
CONCLUSIONS
We suggest that the BIS value is not affected by the administration of remifentanil during intubation under TIVA using propofol.

Keyword

bispectral index; propofol; remifentanil; tracheal intubation

MeSH Terms

Anesthesia
Arterial Pressure
Double-Blind Method
Heart Rate
Humans
Intubation*
Propofol*
Prospective Studies
Unconsciousness
Propofol