Korean J Dermatol.  2003 Aug;41(8):1041-1048.

Effects of Estrogens and Isoflavones on the Collagen Synthesis

• Kim BG
• Oh CK
• Jo JH
• Lee JB
• Kim MB
• Jang HS
• Kwon KS

Abstract

BACKGROUND
The aging of skin is influenced by genetic, environmental, and hormonal factors. Estrogens are the "missing" player in the skin of postmenopausal women. In postmenopausal women, loss of collagen was related to decreased estrogen level. Phytoestrogens, i.e. isoflavone, are plant compounds with estrogen-like biologic activities. OBJECTIVE: The effects of 18beta-estradiol, and isoflavones on production of type I collagen in the fibroblast of postmenopausal woman, keloid and Detroit cell line were examined. METHODS: Type I collagen was measured with procollagen type I C-peptide EIA KIT. RESULTS: 18beta-estradiol and isoflavone enhanced the production of type I collagen in cultured fibroblast of postmenopausal woman and keloid. But isoflavone inhibited the production of collagen in cultured fibroblast of Detroit cell. CONCLUSION: 18beta-estradiol and isoflavone can prevent and improve the cutaneous alterations caused by loss of collagen of postmenopausal women.

Keyword

Isoflavone; Collagen; Estradiol; Postmenopausal woman

MeSH Terms

Aging
C-Peptide
Cell Line
Collagen Type I
Collagen*
Estradiol
Estrogens*
Female
Fibroblasts
Humans
Isoflavones*
Keloid
Phytoestrogens
Plants
Skin
C-Peptide
Collagen
Collagen Type I
Estradiol
Estrogens
Isoflavones
Phytoestrogens