Korean J Anesthesiol.  1992 Aug;25(4):719-725. 10.4097/kjae.1992.25.4.719.

Effects of Halothane , Enflurane and Isoflurane on Hepatic Function in Children

• Kim SD
• Kang BJ

• KMID: 2033002
• DOI: http://doi.org/10.4097/kjae.1992.25.4.719

Abstract

The effects of halothane, enflurane and isoflurane on the postoperative hepatic functions were compared in 91 pediatric patients with normal preoperative hepatic funcions. After induction of anesthesia with thiopental and vecuronium, all the patients were randomly divided into three groups of halothane(n=31), enflurane(n=27) and isoflurane(n=33). Anesthesia was maintained with 1 MAC of each anesthetics combined with N2O(50%) and O2(50%). On the postoperative 1st day(POD#1), we observed elevated total bilirubin in each groups, which was normalized on the postoperative 2nd day(PDO#2). Inthergroup comparisons were not significant. SGOT was elevated on the POD#1, but returned to normal on the POD2 in halothane and isoflurane groups. SGPT showed no changes postoperatively. SGOT and SGPT were not significant between the groups. Alkaline phosphatase showed significant decrease on the POD#2 in enflurane and isoflurane groups, which was statistically significant compared with halothane group.This study shows that halothane, enflurane and isoflurane has no hamful effects on the postoperative hepatic functions, when they are administered in the pediatric patients with normal preoperative hepatic funcions.

Keyword

Anesthetics; halothane; enflurane; isoflurane; liver; hepatic function

MeSH Terms

Alanine Transaminase
Alkaline Phosphatase
Anesthesia
Anesthetics
Aspartate Aminotransferases
Bilirubin
Child*
Enflurane*
Halothane*
Humans
Isoflurane*
Liver
Thiopental
Vecuronium Bromide
Alanine Transaminase
Alkaline Phosphatase
Anesthetics
Aspartate Aminotransferases
Bilirubin
Enflurane
Halothane
Isoflurane
Thiopental
Vecuronium Bromide